Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

The study examined the relationship between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes in 19 males with hair loss and 14 without. Using relative quantitative real-time polymerase chain reaction, it found that expression levels of these genes were lower in normal hair follicle sites compared to sites affected by hair loss in individuals with alopecia. Additionally, there were strong correlations between the expression levels of nucleophosmin and nucleolin, nucleophosmin and UBTF, and nucleolin and UBTF in both groups. The study concluded that there is a significant association between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes.