Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

    February 2016 in “ Genetic Testing and Molecular Biomarkers ”
    Şener Taşdemir, Recep Eröz, Hasan Serkan Doğan, Haktan Bağış Erdem, İ̇brahim Şahin, Murat Kara, Ragıp İsmail Engin, Hasan Türkez
    Image of study
    TLDR Hair loss is significantly linked to lower levels of certain genes in hair follicles.
    The study examined the relationship between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes in 19 males with hair loss and 14 without. Using relative quantitative real-time polymerase chain reaction, it found that expression levels of these genes were lower in normal hair follicle sites compared to sites affected by hair loss in individuals with alopecia. Additionally, there were strong correlations between the expression levels of nucleophosmin and nucleolin, nucleophosmin and UBTF, and nucleolin and UBTF in both groups. The study concluded that there is a significant association between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  49 upvotes 2 years ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community Hair loss journey from 01 24 to 06 25 / HT and 5ARI only

      in Progress Pictures  122 upvotes 1 week ago
      A 28-year-old male shares his hair loss journey, starting with a hair transplant in February 2024 and using finasteride, later switching to dutasteride in January 2025. He has not used minoxidil and is satisfied with the results, despite some side effects like temporary nipple pain and a spike in libido.

      community Temporalis Hypertrophy and hair loss

      in Treatment  24 upvotes 2 weeks ago
      Hair loss treatments include finasteride, minoxidil, and scalp exercises. Opinions vary on the effectiveness, with some attributing hair loss to muscle tension and inflammation, while others focus on genetics and DHT.

      community Hair loss journey on the scalp (finasteride only)

      in Progress Pictures  26 upvotes 3 weeks ago
      A user shared their positive hair loss journey using 1mg/day oral finasteride, showing significant improvement after 8-9 months without side effects. They expressed relief in having control over their hair loss and are open to questions about their experience.

    Related Research

    1 / 1 results