Cardioprotective Effect of Royal Jelly on Paclitaxel-Induced Cardiotoxicity in Rats

The study demonstrated that royal jelly (RJ) had a protective effect against paclitaxel (TXL)-induced cardiotoxicity in adult male Wistar rats (n=48). TXL administration increased oxidative and nitrosative stress markers, such as malondialdehyde (MDA) and nitric oxide (NO), and elevated the cardiac biomarker creatine kinase (CK-MB), causing significant heart damage. RJ, administered in a dose-dependent manner, significantly reduced these stress markers and CK-MB levels, and improved heart tissue conditions. The findings suggested that RJ could mitigate TXL-induced cardiotoxicity by suppressing oxidative and nitrosative stress, indicating its potential as a therapeutic agent for protecting against chemotherapy-induced heart damage.