Cardioprotective Effect of Royal Jelly on Paclitaxel-Induced Cardiotoxicity in Rats

    February 2016 in “ PubMed ”
    Hassan Malekinejad, Sima Ahsan, Fatemeh Delkhosh-Kasmaie, Hadi Cheraghi, Ali Rezaei-Golmisheh, Hamed Janbazacyabar
    TLDR Royal jelly can protect the heart from damage caused by paclitaxel.
    The study demonstrated that royal jelly (RJ) had a protective effect against paclitaxel (TXL)-induced cardiotoxicity in adult male Wistar rats (n=48). TXL administration increased oxidative and nitrosative stress markers, such as malondialdehyde (MDA) and nitric oxide (NO), and elevated the cardiac biomarker creatine kinase (CK-MB), causing significant heart damage. RJ, administered in a dose-dependent manner, significantly reduced these stress markers and CK-MB levels, and improved heart tissue conditions. The findings suggested that RJ could mitigate TXL-induced cardiotoxicity by suppressing oxidative and nitrosative stress, indicating its potential as a therapeutic agent for protecting against chemotherapy-induced heart damage.
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