Epidemiological Study of Prostate Cancer (EPICAP): A Population-Based Case-Control Study in France

    February 2014 in “ BMC Cancer ”
    F. Ménégaux, Antoinette Anger, Hasina Randrianasolo, Claire Mulot, Pierre Laurent‐Puig, F. Iborra, Jean-Pierre Bringer, Benoit Leizour, Rodolphe Thuret, Pierre‐Jean Lamy, Xavier Rébillard, Brigitte Trétarre
    TLDR Circadian rhythm disruption, chronic inflammation, hormones, metabolism, and genetics may increase prostate cancer risk.
    The EPICAP study was a population-based case-control study conducted in Hérault, France, involving 1,000 prostate cancer cases and 1,000 controls under 75 years old, from 2012 to 2014. It aimed to investigate environmental and genetic factors contributing to prostate cancer, focusing on circadian disruption, chronic inflammation, hormonal and metabolic influences, and genetic predispositions. The study highlighted the potential carcinogenic role of circadian rhythm disruption, the association of chronic inflammation with prostate cancer, and the complex interplay of hormones and metabolism in cancer development. It also explored genetic factors, noting familial aggregation and specific gene polymorphisms associated with prostate cancer risk. The research underscored the importance of understanding these multifaceted risk factors to improve prostate cancer etiology and prognostic assessments.
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