2 citations
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February 2019 in “JOJ dermatology & cosmetics” The study found that Anagen grow, a herbal serum, promotes hair growth elongation and may inhibit the alpha reductase enzyme, suggesting it as a safe, effective alternative to finasteride and beneficial alongside minoxidil for reducing scalp dryness.
22 citations
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March 2017 in “Scientific reports” This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.
12 citations
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June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.
9 citations
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August 2019 in “Journal of The European Academy of Dermatology and Venereology” Minoxidil activation by hair enzymes predicts treatment success for female hair loss.
35 citations
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October 2013 in “Journal of Dermatological Science” This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.
1 citations
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April 2024 in “Journal of Dermatological Science” 2 citations
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July 2004 in “Cell Biology International” This study found that urokinase plasminogen activator (uPA) is elevated in hyperproliferative hair follicle keratinocytes in mice, and its inhibition significantly reduces their proliferation.
77 citations
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February 2001 in “Journal of Dermatological Science” HGF activator helps convert HGF to its active form, promoting hair growth.
105 citations
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May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that activation of the TRPV3 ion channel inhibits human hair growth by affecting hair follicles and outer root sheath keratinocytes.
20 citations
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February 2016 in “American Journal of Pathology” This study indicates that the OVOL1-OVOL2 axis may play a significant role in hair follicle differentiation and growth, potentially serving as therapeutic targets for hair disorders like alopecia and in the tumorigenesis of pilomatricoma.
September 2016 in “Journal of dermatological science” The researchers reported that the OVOL1-OVOL2 axis may play a role in hair follicle differentiation and tumorigenesis, and OVOL1 and OVOL2 are potential diagnostic markers for pilomatricoma and pilomatrix carcinoma.
May 2017 in “Journal of The American Academy of Dermatology” LED light helps human hair root cells grow and move by activating certain cell pathways.
25 citations
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September 2018 in “Scientific Reports” This study found that morroniside enhanced hair follicle growth and transition through the Wnt/β-catenin signaling pathway in a mouse model, suggesting its potential as a treatment for hair loss.
July 2024 in “Experimental Dermatology” This study suggests that APC collagen peptides may accelerate hair growth and promote overall hair health by enhancing cellular proliferation and activating specific signaling pathways in human and mouse models.
May 2019 in “Journal of Clinical Dermatology” This study found that metformin, an AMPK activator, promoted hair growth in vitro by enhancing the AMPK/β-catenin signaling pathway in dermal papilla and outer root sheath cells.
6 citations
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July 2012 in “Experimental Dermatology” In this study, treatment with human follicular keratinocyte-conditioned media improved the trichogenicity of cultured dermal cells by activating key signalling pathways, suggesting its potential use in cell therapy for hair loss.
4 citations
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June 2022 in “Journal of Cosmetic Dermatology” This study suggests that dermal fibroblast-conditioned medium containing multi-peptide factors may stimulate hair growth by enhancing growth factor expression and β-catenin regulation in hair follicle cells.
July 2024 in “Frontiers in Pharmacology” This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.
July 2024 in “International Journal of Pharmacognosy and Life Science” This review highlights several natural ingredients, including Citrus Sinensis, Nigella sativa, flax seed, and coconut oil, that may promote hair growth and prevent hair loss due to their protective and nourishing properties, focusing on their formulation into hair serum.
23 citations
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September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this mouse study, NF-κB was shown to play a role in hair follicle cycling and morphogenesis, with specific activity patterns differing by hair type and involving noncanonical signaling for zigzag hair bending.
35 citations
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January 2011 in “Journal of Biological Chemistry” This study found that overexpression of sPLA2-X in mice was associated with alopecia and hair follicle abnormalities, highlighting its potential role in hair follicle homeostasis.
9 citations
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September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” In this study, researchers found that the matriptase-HGF-c-MET pathway may be activated in proliferative cells of human hair follicles and sebaceous glands, suggesting a potential role in hair growth regulation.
27 citations
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January 2006 in “Colloids and Surfaces B: Biointerfaces” This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.
43 citations
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December 2006 in “The American journal of pathology” This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.
January 2002 in “Basic medical sciences and clinics” This review explores hypotheses about hair follicle stem cell function in morphogenesis and cycling, highlights the importance of dermal papilla cells and signaling pathways, and provides no new clinical findings.
This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.
This presentation suggests that the activation of TRPV3 channels by fruit acids and carvacrol contributes to exfoliation and may underlie the skin-resurfacing effects of chemical peels.
169 citations
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June 2010 in “Molecular & cellular proteomics” This study suggests that ethylene and lignoceric acid (C24:0) may promote cotton fiber and Arabidopsis root hair growth by activating the pectin biosynthesis network.
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study explored how root hairs integrate opposing growth signals but did not report new conclusive findings on the activation of known molecular players in polar growth.
4 citations
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August 2025 in “Plant Cell & Environment” This study found that the plant-growth-promoting bacteria Azospirillum brasilense enhances root hair development by increasing auxin levels and activating specific transcription factors, highlighting key signaling pathways involved in this process.