Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice

    June 2026 in “ Cells ”
    Hangzhen Zhou, Jiaxin Liu, Lie Yang … S H Li
    Studysummary This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.
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    Research cited in this study 13

    1. Dynamic Interplay Between IL-1 and WNT Pathways in Regulating Dermal Adipocyte Lineage Cells During Skin Development and Wound Regeneration Cell Reports · 2023
    2. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    3. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    4. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020
    5. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    6. Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat Cells · 2020
    7. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    8. Effects of Hair Follicle Stem Cells on Partial-Thickness Burn Wound Healing and Tensile Strength Iranian Biomedical Journal · 2019
    9. Pten Loss In Lgr5+ Hair Follicle Stem Cells Promotes SCC Development Theranostics · 2019
    10. Isolation and Characterization of Hair Follicle Stem Cells from Arbas Cashmere Goat Cytotechnology · 2016
    11. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    12. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    13. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013