Activation of Temperature-Sensitive Ca2+-Permeable TRPV3 Channels by Natural α-Hydroxyl Acids Causes Exfoliation for Skin-Resurfacing
January 2020
TLDR Natural α-hydroxyl acids cause skin exfoliation by activating TRPV3 channels.
The study presented evidence that the activation of temperature-sensitive Ca2+-permeable TRPV3 channels by natural α-hydroxyl acids (AHAs) caused exfoliation for skin resurfacing. It was found that TRPV3 channels in keratinocytes were activated by intracellular acidification induced by glycolic acid, leading to direct activation of TRPV3 and promoting cell death. A critical N-terminal histidine residue, His-426, was identified as essential for sensing intracellular proton levels. Additionally, pharmacological activation of TRPV3 by natural carvacrol induced cell death in hair follicle outer root sheath cells and inhibited hair growth in mice. These findings suggested that TRPV3-mediated proton sensing and cell death in keratinocytes could be the molecular basis for the cosmetic use of AHAs and their potential in treating acidic pH-related skin disorders.
