research Activation of Temperature-Sensitive Ca2+-Permeable TRPV3 Channels by Natural α-Hydroxyl Acids Causes Exfoliation for Skin-Resurfacing
Natural α-hydroxyl acids cause skin exfoliation by activating TRPV3 channels.
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5 / 1000+ resultsresearch Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3
Acid can block TRPV3 from outside the cell but boost its function from inside.
research Past and Future Strategies for GPCR Deorphanization
Finding functions for unknown GPCRs is hard but key for making new drugs.
research Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology
Metabolic signals and cell shape influence how cells develop and change.
research Selective Sensing of Darolutamide and Thalidomide in Pharmaceutical Preparations and in Spiked Biofluids
A new, efficient method has been developed to detect darolutamide and thalidomide, drugs used for certain hair loss and prostate cancer treatments, in pharmaceuticals and body fluids.
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5 / 9 resultscommunity Binding affinity of pyrilutamide!
Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.
community 6 month progress. Fin/Min daily.
A user's 6 month progress using finasteride and minoxidil as treatments for hair loss, with the replies discussing side effects and general consensus about usage of the two medications.
community [Theory] Big Bald is deliberately delaying the cure indefinitely
The conversation humorously suggests that the hair loss industry, referred to as "Big Bald," deliberately delays a cure to profit from ongoing treatments like minoxidil, finasteride, and dutasteride. Participants debate whether a cure would be more profitable than current treatments, with some suggesting that the industry prefers continuous treatments for sustained profit.
community 3 months progress- back from the dead?
A 32-year-old is documenting their 3-month progress in treating hair loss using 0.5 mg dutasteride, topical and 5 mg oral minoxidil, and Ducray Anaphase+ shampoo daily. They report slight libido reduction and increased eyebrow hair but are generally satisfied with the results and considering a hair transplant after a year.
community 23male 10month finasteride and minoxidil
A 23-year-old male experienced good hair growth and increased self-confidence after 10 months of using oral finasteride (1.25mg) and topical minoxidil (5% twice a day), despite no decrease in hair shedding. He also used 1mm microneedling monthly and reported minor side effects like forgetfulness.