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Microneedles are effective for drug delivery, vaccinations, fluid extraction, and treating hair loss, with advancements in manufacturing like 3D printing.

CXXC5 can both suppress and promote cancer, making it a complex target for treatment.

CD34+ and CD34- melanocyte stem cells have different regenerative abilities.

Different species use the same genes for tooth regeneration.

Normal human melanocytes can avoid cell death through multiple pathways.

Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.

In September 2016, there were major advancements and promising clinical trials in stem cell research and regenerative medicine.

Nanoformulations improve luteolin's effectiveness as a cancer treatment.

Cellular and immunotherapies show promise for healing chronic wounds but need more research.

Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.

Vitamin D is crucial for bone health and preventing serious diseases.

Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.

Plant-based compounds can improve wound dressings and skin medication delivery.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Finasteride-loaded nanoparticles may help treat alopecia.

*Acorus calamus* has many medicinal benefits but needs more safety research.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.

Different types of skin stem cells can change and adapt, which is important for developing new treatments.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

New drug delivery methods can make natural compounds more effective and stable.