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    Glossary Hair Cycle Clock

    internal mechanism regulating hair growth, rest, and shedding phases

    The Hair Cycle Clock refers to the internal biological mechanism that regulates the phases of hair growth, rest, and shedding. This cycle includes the anagen (growth), catagen (transitional), and telogen (resting) phases, ensuring that hair follicles undergo a synchronized process of renewal and shedding. Understanding this clock is crucial for diagnosing and treating hair disorders like alopecia.

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    1. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 116 citations
    2. A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013 · 92 citations
    3. 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles 2022
    4. 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock? 2021
    5. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations
    6. Overview of the Circadian Clock in the Hair Follicle Cycle Biomolecules · 2023
    7. Principles of Hair Cycle Control The Journal of Dermatology · 1998 · 109 citations
    8. Clock genes, hair growth and aging Aging · 2010 · 55 citations
    9. Hair Follicles as a Critical Model for Monitoring the Circadian Clock International Journal of Molecular Sciences · 2023 · 5 citations
    10. Bioorthogonal Click-Engineered Microneedle Patch Enables Adeno-Associated Virus-Mediated Dermal Acidic Fibroblast Growth Factor Expression for Hair Loss Treatment ACS Nano · 2026
    11. Identification of lncRNAs involved in the hair follicle cycle transition of cashmere goats in response to photoperiod change BMC Genomics · 2025 · 1 citations
    12. Hair follicles and their role in skin health Expert Review of Dermatology · 2006 · 16 citations
    13. Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche Nature communications · 2023 · 1 citations
    14. The Circadian Clock in Skin Journal of Biological Rhythms · 2015 · 127 citations
    15. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006 · 224 citations
    16. PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells Stem cell reports · 2017 · 22 citations
    17. Stem cells and the circadian clock Developmental biology · 2017 · 75 citations
    18. Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition Communications biology · 2024
    19. Estimation methods for human circadian phase by use of peripheral tissues Hypertension research · 2016 · 14 citations
    20. Transcriptomic regulation of seasonal coat color change in hares Ecology and evolution · 2020 · 18 citations
    21. Resting no more: re‐defining telogen, the maintenance stage of the hair growth cycle Biological Reviews · 2014 · 120 citations
    22. Identification of Telogen Markers Underscores that Telogen Is Far from a Quiescent Hair Cycle Phase 2011 · 21 citations
    23. The clock within Nature · 2011 · 6 citations
    24. The control of hair growth: An overview Journal of Investigative Dermatology · 1993 · 62 citations
    25. Circadian rhythm sleep-wake disorders (CRSWDs): Linking circadian misalignment to adverse health outcomes. EBioMedicine · 2020 · 5 citations
    26. Repeatable Perming via Thiol–Michael Click Reaction: Using Amide Derived from Maleic Acid and Cystine Molecules · 2026
    27. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005 · 205 citations
    28. Hair, Cutaneous Homeostasis and Stem Cell Functions Journal of Investigative Dermatology · 2014
    29. Possible contribution of chronobiology to cardiovascular health Frontiers in physiology · 2014 · 29 citations
    30. The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 4 citations