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    Glossary Hair Bulge

    region in hair follicle housing stem cells for growth

    The hair bulge is a region located in the outer root sheath of the hair follicle, near the base of the hair shaft. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for the repair of the skin after injury. This area plays a significant role in the hair growth cycle and is a key focus in research on hair loss and regenerative medicine.

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    Research 30 of 1000+

    1. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    2. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    3. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge Experimental Dermatology · 2009 · 18 citations
    4. Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis Life science alliance · 2020 · 5 citations
    5. Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report Oncology Letters · 2016
    6. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    7. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    8. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    9. Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells International Journal of Molecular Sciences · 2025
    10. 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity 2019
    11. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    12. Hair follicle bulge-derived stem cells promote tissue regeneration during skin expansion Biomedicine & Pharmacotherapy · 2020 · 27 citations
    13. Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration Stem Cells · 2014 · 13 citations
    14. Regenerative potential of CD200- subpopulations of hair follicle bulge Frontiers in Cell and Developmental Biology · 2026
    15. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    16. 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation 2023
    17. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    18. GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells npj regenerative medicine · 2020 · 7 citations
    19. 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion Journal of Investigative Dermatology · 2019
    20. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003 · 561 citations
    21. Characterization and isolation of stem cell-enriched human hair follicle bulge cells 2005 · 550 citations
    22. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons Proceedings of the National Academy of Sciences · 2005 · 419 citations
    23. Dissecting the bulge in hair regeneration Journal of Clinical Investigation · 2012 · 86 citations
    24. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia? Clinical and Experimental Dermatology · 2009 · 39 citations
    25. Bulge cells of human hair follicles: segregation, cultivation and properties Colloids and Surfaces B: Biointerfaces · 2006 · 27 citations
    26. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    27. Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge Journal of Investigative Dermatology · 2005 · 17 citations
    28. Keratinocytes-hair follicle bulge stem cells-fibroblasts co-cultures on a tri-layer skin equivalent derived from gelatin/PEG methacrylate nanofibers Journal of Biomaterials Science Polymer Edition · 2020 · 11 citations
    29. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    30. Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development Frontiers in cell and developmental biology · 2020 · 10 citations