Line-Field Optical Coherence Tomography: Usefulness in the Non-Invasive Differential Diagnosis of Congenital Alopecia of Infancy

    July 2024 in “ Dermatology Practical & Conceptual ”
    Linda Tognetti, Giulia Galluccio, Teresa Oranges, Elisa Pianigiani, Francesca Ierardi, Élisa Cinotti, Pietro Rubegni
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    Studysummary This article discusses the diagnostic challenges between certain neonatal scalp conditions and highlights the potential of line-field confocal optical coherence tomography to provide detailed, non-invasive skin examination, without presenting new clinical findings.
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    Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive tool for the differential diagnosis of congenital alopecia in infants, such as nevus sebaceous of Jadassohn (NSJ), congenital triangular alopecia (CTA), and aplasia cutis congenita (ACC). These conditions can be difficult to distinguish shortly after birth due to overlapping dermoscopic features influenced by scalp skin morphology and maturation. LC-OCT offers detailed morphological skin insights with cellular resolution, facilitating more accurate diagnoses in atypical cases.
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