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PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

In this case series, researchers reported an unexpectedly rapid and positive response to a topical, hydrogel-based botanical treatment for androgenetic alopecia in both male and female volunteers, achieving significant improvement in hair loss within 90 days instead of the planned 270 days.

This review discusses recent advancements in triboelectric nanogenerator-based electronics for clinical applications and reports no new experimental results, focusing on customization for chronic disease diagnosis and long-term treatment.

This study suggests that extrasynaptic δGABA-A receptors may have a protective role in modulating the severity of catamenial-like seizures by influencing neurosteroid and benzodiazepine responses in mice.

This study found that Ashwagandha-derived nanovesicles increased cell proliferation, angiogenesis, and growth factor expression in vitro, suggesting they may have potential as a plant-based alternative or complement to current therapies for hair and skin conditions.

Ashwagandha-derived nanoparticles can promote human hair growth.

The researchers reported that topical tofacitinib in mice increased hair follicles in the growth phase and boosted noggin and BMP4 mRNA expressions, compared to a vehicle and minoxidil.

This study demonstrated that the Epidermal Biopotential Sensing System (EBSS) can measure digital biomarkers of pain in mice, suggesting potential applications in assessing pain and screening analgesics in populations with communication difficulties.

This study found that topical cepharanthine increased IGF-I production in human dermal papilla cells, suggesting it may stimulate hair growth and be a promising treatment option for androgenetic alopecia.

Ashwagandha nanoparticles help hair grow by increasing a growth factor.

This study found that GPR40 agonists may promote hair growth by inducing angiogenesis via specific molecular pathways in both cell and animal models, suggesting potential for hair loss treatment.

This review explores the role of advanced glycation end products in skin aging and their interaction with oxidative stress, but reports no new clinical findings.

This study examined the skin transcriptomic differences between Jiangnan and Changthangi cashmere goats, identifying 4,942 differentially expressed genes that may contribute to variations in cashmere quality, with notable enrichment in various signaling pathways and structural components of hair follicles.

In this study of a postmenopausal woman with hyperandrogenism, GnRH agonist treatment significantly reduced testosterone levels, suggesting the androgen excess was ovarian in origin and indicating the potential of using GnRH agonists as a conservative treatment option when surgery is not feasible.

This study found that niosomal aminexil was more clinically effective for hair growth than conventional aminexil solutions, and that niosomes facilitated aminexil penetration through rat skin without propylene glycol.

This article reviews treatments for progeria, including aspirin, hydrotherapy, and farnesyl transferase inhibitors, but reports no new clinical results.

This study found that nociplastic type pain is a complex and heritable trait, with significant genetic overlap with multisite chronic pain and some connection to rheumatoid arthritis and a neuropathic pain phenotype.

This study found that a mixture of Red-BCQ and Agnex extract promoted greater hair growth and antioxidant effects in C57BL/6 mice compared to other groups, including minoxidil treatment.

This study measured plasma testosterone glucosiduronate levels and found no overlap in those with hyperandrogenism compared to normal females, despite normal testosterone and dihydrotestosterone levels in half of the affected patients.

This study illustrates the severe neonatal clinical presentation of Netherton syndrome, which can be fatal despite intensive care, highlighting a specific homozygous mutation (c.1431-12G > A) associated with lethal cases.

This study describes a multifunctional hydrogel system designed to treat androgenetic alopecia by integrating nanozymes for reactive oxygen species clearance and melanin nano photothermal agents to enhance hair follicle health, suggesting potential for multi-target precision therapy and improved hair growth.

This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.

This study investigated the mechanisms of Platycladi Cacumen in treating androgenetic alopecia, identifying potential key components and targets but found no specific targets or regulatory mechanisms.

This study found that HDAC6 plays a crucial role in regulating primordial follicle activation, with its overexpression delaying activation and preserving fertility by reducing NGF levels.

Hair follicle dermal stem cells help control hair growth timing by regulating signals at the hair germ–dermal papilla interface.

This case report describes a woman who developed extensive nonscarring inflammatory hair loss after two years of gefitinib treatment, highlighting potential cutaneous side effects associated with epidermal growth factor receptor blockers.

This study indicates that Fructus panax ginseng extract may promote hair growth by increasing proliferation in human hair dermal papilla cells and lengthening the anagen phase in mice.

This study suggests that BTP levels in cerebrospinal fluid might help diagnose CIDP and predict therapy response but require validation in larger cohorts.

This case study describes a 54-year-old man with an E600A mutation in the NOD-2 gene associated with Blau syndrome, who presented with skin involvement, differing from typical cases, and initially responded to colchicine treatment.

This study found that administering lower doses of sodium pentaborate pentahydrate increased hair growth in rats via specific molecular pathways, while a higher dose suppressed these pathways and impaired hair growth.