HDAC6-Dependent Deacetylation of NGF Dictates Its Ubiquitination and Maintains Primordial Follicle Dormancy

    January 2024 in “ Theranostics ”
    Tuo Zhang, Yuntong Tong, Ruxin Zhu, Yao-Yun Liang, Jixian Zhang, Chujiao Hu, Meina He, Hongwei Zhu, Zhongzhou Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Lei Shan, Zhirui Zeng, Yinuo Wu, Zhongjun Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen
    Image of study
    TLDR HDAC6 helps keep ovarian follicles dormant, extending female fertility.
    The study investigates the role of histone deacetylase 6 (HDAC6) in maintaining primordial follicle dormancy and female fertility. Using human ovarian samples, granulosa cells from DOR patients, an Hdac6-overexpressing mouse model, and RNA sequencing, researchers found that HDAC6 is highly expressed in dormant primordial follicles and decreases with reproductive aging. Overexpression of Hdac6 delayed follicle activation, extending reproductive lifespan, while short-term HDAC6 inhibition promoted follicle activation. Mechanistically, HDAC6 interacts with NGF, reducing its acetylation and increasing its degradation, thus maintaining follicle dormancy. The findings highlight HDAC6's role in fertility preservation by regulating NGF levels.
    Discuss this study in the Community →

    Related Community Posts Join

    3 / 3 results

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 2 months ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  51 upvotes 1 month ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

    Similar Research

    5 / 303 results