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Glossary Granulosa Cells

specialized cells that nourish and support developing ovarian eggs

Granulosa cells are specialized cells that surround and nourish developing eggs in the ovaries. They play a crucial role in the maturation of the egg and the production of hormones like estrogen, which are essential for reproductive health.

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Research

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Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

In this study, researchers observed that hyperandrogenic PCOS patients exhibited distinct miRNA and TGFβ signaling gene expression patterns in granulosa cells, suggesting these factors may play a role in PCOS pathogenesis.

Higher PDCD4 Expression Is Associated With Obesity, Insulin Resistance, Lipid Metabolism Disorders, And Granulosa Cell Apoptosis In Polycystic Ovary Syndrome

research Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome

34 citations , February 2016 in “Fertility and Sterility”

This study suggests that higher PDCD4 expression may play a significant role in polycystic ovary syndrome pathogenesis through its association with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis.

Role of OCT4 in the Regulation of FSH-Induced Granulosa Cell Growth in Female Mice

research Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice

14 citations , January 2020 in “Frontiers in Endocrinology”

This study reports that in ovarian cell development, FSH-induced OCT4 expression is regulated through the GSK3β/β-catenin pathway mediated by the PI3K/Akt pathway.

research Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome

3 citations , June 2025 in “Drug Design Development and Therapy”

This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.

research Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions

3 citations , April 2024 in “Molecular Human Reproduction”

This study found that paxillin knockdown in human granulosa-derived cells and mouse models decreased androgen receptor protein levels and altered gene expression, suggesting paxillin's role in protecting against androgen excess effects, as observed in a polycystic ovary syndrome mouse model.

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community Effect of melatonin on aromatase expression

4 upvotes 4 years ago

Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.

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