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Did you mean Histone Deacetylases?

GlossaryHistone Deacetylases

enzymes that remove acetyl groups from histone proteins

Histone Deacetylases (HDACs) are enzymes that remove acetyl groups from histone proteins, leading to a more compact and less accessible form of DNA. This process can suppress gene expression by making it harder for transcription factors to access the DNA. HDACs play a crucial role in regulating gene activity and are involved in various biological processes, including cell cycle progression and differentiation.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Stem Cell-Derived Motor Neurons from Spinal and Bulbar Muscular Atrophy Patients

48 citations, June 2014 in “Neurobiology of Disease”

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

research HDAC6-Dependent Deacetylation of NGF Dictates Its Ubiquitination and Maintains Primordial Follicle Dormancy

January 2024 in “Theranostics”

HDAC6 helps keep ovarian follicles dormant, extending female fertility.

research Foxp3 Post-Translational Modifications and Treg Suppressive Activity

82 citations, October 2019 in “Frontiers in Immunology”

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

research Determination of Adulteration in Hair Serums by LC-HRMS

June 2023 in “Journal of chemical metrology”

A new method found unlisted drugs in two popular hair serums, posing a health risk.

research Alcohol and Prostate Cancer: Time to Draw Conclusions

9 citations, February 2022 in “Biomolecules”

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

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community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.