Diagnostic And Therapeutic Utility Of Gonadotrophin-Releasing Hormone Agonist In Postmenopausal Hyperandrogenism Of Ovarian Origin

July 2023 in “ Journal of the ASEAN Federation of Endocrine Societies ”

Murizal Zainol, Rosliza Shafie, Noor Rafhati Adyani Abdull

gonadotrophin-releasing hormone agonist GnRH agonist postmenopausal hyperandrogenism hirsutism acne testosterone androgen excess

TLDR GnRH agonist effectively diagnoses and treats postmenopausal hyperandrogenism from ovarian sources.

The study discusses the use of gonadotrophin-releasing hormone (GnRH) agonist as a diagnostic and therapeutic tool for postmenopausal hyperandrogenism of ovarian origin. A 71-year-old female with hirsutism and acne was treated with GnRH agonist, resulting in a significant reduction in testosterone levels (98.6% reduction) and clinical improvement, confirming the ovarian source of androgen excess. The study concludes that GnRH agonist can be a valuable tool for evaluating and conservatively treating postmenopausal hyperandrogenism, especially for patients who are not candidates for surgery.

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