Lack of Association Between Clinical and Biochemical Hyperandrogenism in Patients With Polycystic Ovary Syndrome

    September 2008 in “ Fertility and Sterility
    Erica Johnstone, J.R. Sandler, J.D. Lamb, W.C. Shelly, Marcelle I. Cedars, Heather G. Huddleston
    Image of study
    TLDR Clinical signs of excess male hormones and actual hormone levels in the blood do not always match in women with polycystic ovary syndrome.
    In a study from 2008, researchers investigated the relationship between clinical and biochemical hyperandrogenism in patients with polycystic ovary syndrome (PCOS). The cross-sectional study included 94 patients who met the Rotterdam diagnostic criteria for PCOS, with 62 being analyzed after excluding those using hormonal contraceptives. The results showed that 87% of the patients had clinical hyperandrogenism, while only 51% had biochemical hyperandrogenism. There was a trend suggesting that those with clinical hyperandrogenism were less likely to have biochemical hyperandrogenism (46% vs. 83% without clinical hyperandrogenism, p = 0.09). No significant relationship was found between clinical signs of hyperandrogenism, such as acne, hirsutism, and androgenic alopecia, and biochemical hyperandrogenemia. The study concluded that clinical and biochemical hyperandrogenism are distinct entities in PCOS, and serum androgen evaluation is necessary for diagnosis in patients presenting with oligomenorrhea.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  8 upvotes 1 year ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Spironolactine Update: 2 months (34, Female)

      in Female  23 upvotes 8 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 11 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

    Related Research

    1 / 1 results