Hutchinson-Gilford Progeria Syndrome - A Brief Introduction
June 2018
in “
International Journal of Pharmacological Research
”
Studysummary This article reviews treatments for progeria, including aspirin, hydrotherapy, and farnesyl transferase inhibitors, but reports no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Hutchinson-Gilford Progeria Syndrome (HGPS) was a genetic disorder characterized by symptoms resembling accelerated aging, such as alopecia, low body weight, decreased joint mobility, and cardiovascular disease. It was caused by a mutation in the LMNA gene, which affected the production of Lamin A and Lamin C proteins. Treatments included aspirin to prevent cardiovascular issues, hydrotherapy for joint mobility, and farnesyl transferase inhibitors (FTIs) to reduce disease severity by blocking progerin farnesylation. Additionally, fluoride and vitamin supplements were recommended for patients with progeria.
