Development of a Mouse Model for Hutchinson-Gilford Progeria Syndrome Reveals Defects in Adult Stem Cell Maintenance

    March 2011 in “ Open Archive (Karolinska Institutet) ”
    Ylva Rosengardten
    Studysummary This study explored the effects of a common Hutchinson-Gilford progeria syndrome mutation in an inducible mouse model, revealing skin abnormalities similar to those in affected patients.
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    Research cited in this study 10

    1. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    2. More Than One Way to Skin Genes & Development · 2008
    3. Scratching the Surface of Skin Development Nature · 2007
    4. The Hair Cycle Journal of Cell Science · 2006
    5. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    7. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    8. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    9. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    10. The Epidermis: Rising to the Surface Current opinion in genetics & development · 1994