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    Glossary Progerin

    defective protein causing premature aging in Hutchinson-Gilford Progeria Syndrome

    Progerin is a defective protein that is produced in cells due to a mutation in the LMNA gene, which normally codes for the lamin A protein. This abnormal protein is associated with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder that causes accelerated aging in children. Progerin disrupts the normal structure and function of the cell nucleus, leading to various symptoms of premature aging.

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    Research 10 of 186

    1. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease Journal of Cell Science · 2008 · 85 citations
    2. Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells Cells · 2019 · 51 citations
    3. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin Human Molecular Genetics · 2008 · 48 citations
    4. Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment Cells · 2019 · 39 citations
    5. Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis EMBO molecular medicine · 2019 · 11 citations
    6. Hutchinson-gilford progeria syndrome and its relevance to cardiovascular diseases and normal aging. PubMed · 2013 · 3 citations
    7. Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case Вопросы современной педиатрии · 2022 · 1 citations
    8. Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome International journal of molecular sciences · 2022 · 1 citations
    9. Genetics of Progeria and Aging Elsevier eBooks · 2018
    10. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance Open Archive (Karolinska Institutet) · 2011
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    1. On Fin 5 days a week and dut twice a week and still rapidly losing hair. HOW?? 9 months on fin! Reddit · 24 Sept 2022

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