Plasma Testosterone Glucosiduronate: A Reliable Indicator of Female Hyperandrogenism (Idiopathic Hirsutism and Androgenic Alopecia)

    November 1980 in “ Clinical Endocrinology ”
    J. Tamm, U. Volkwein, Jesús A.F. Tresguerres
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    TLDR Measuring plasma testosterone glucosiduronate is a reliable way to detect high male hormone levels in women.
    The study from 1980 examined the effectiveness of measuring plasma testosterone glucosiduronate (TG) levels as an indicator of female hyperandrogenism, including idiopathic hirsutism and androgenetic alopecia. It involved 17 normal females, 20 females with idiopathic hirsutism, and 12 females with androgenetic alopecia. The results showed that mean plasma TG concentrations were significantly higher in females with hyperandrogenism (1.42 ± 0.55 ng/ml for hirsutism and 0.96 ± 0.22 ng/ml for alopecia) compared to the control group (0.47 ± 0.18 ng/ml). The study found that plasma TG was a more reliable indicator of hyperandrogenism than urinary TG excretion and was easier to measure than free plasma testosterone, despite about 50% of hyperandrogenic patients having normal levels of plasma testosterone and dihydrotestosterone.
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