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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Dosing time affects finasteride's effectiveness and safety in rats.

The glucocorticoid receptor helps protect skin from tumors and other issues.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

Certain medications can impact metabolic syndrome, with some improving conditions like high blood sugar and others having no effect.

Adrenal disorders can cause lasting brain and behavior issues in children.

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Hormones and genes affect hair growth and male baldness.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

SGK3 is essential for proper hair growth and health.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Glucocorticoid treatment in lupus can cause oral lesions, which need early diagnosis and comprehensive care.