TLDR The glucocorticoid receptor helps protect skin from tumors and other issues.
The study by Latorre et al. demonstrated that the glucocorticoid receptor (GR) played a crucial role in skin physiology and pathology, with its signaling having anti-proliferative and anti-inflammatory effects. Mice lacking GR in the epidermis were more susceptible to chemical carcinogenesis, indicating GR's protective role against tumors. The research highlighted the need for precise regulation of glucocorticoids, as both excessive and insufficient GR activity could lead to skin pathologies. GR signaling was also implicated in skin aging and various skin disorders, suggesting that further research could provide deeper insights into skin health and disease mechanisms.
40 citations,
November 2009 in “Experimental Dermatology” The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.
67 citations,
August 2007 in “American Journal of Pathology” Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.
42 citations,
March 2008 in “Molecular and Cellular Endocrinology” Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
9 citations,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
109 citations,
October 2007 in “Journal of pineal research” Melatonin helps regulate hair growth and protects the hair follicle from stress.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
Editing the FGF5 gene in sheep increases fine wool growth.
