Growing an Epidermal Tumor

The study by Latorre et al. demonstrated that the glucocorticoid receptor (GR) played a crucial role in skin physiology and pathology, with its signaling having anti-proliferative and anti-inflammatory effects. Mice lacking GR in the epidermis were more susceptible to chemical carcinogenesis, indicating GR's protective role against tumors. The research highlighted the need for precise regulation of glucocorticoids, as both excessive and insufficient GR activity could lead to skin pathologies. GR signaling was also implicated in skin aging and various skin disorders, suggesting that further research could provide deeper insights into skin health and disease mechanisms.