Exercise Activates the PI3K-AKT Signal Pathway by Decreasing the Expression of 5α-Reductase Type 1 in PCOS Rats

    May 2018 in “ Scientific reports ”
    Chuyan Wu, Feng Jiang, Ke Wei, Zhongli Jiang
    Studysummary This study found that exercise decreases the expression of 5αR1, thereby enhancing the PI3K/AKT signaling pathway in PCOS rats.
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    Research cited in this study 6

    1. 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Reproductive Biology and Endocrinology · 2017
    2. Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group Fertility and sterility · 2011
    3. Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats Journal of Pharmacology and Experimental Therapeutics · 2011
    4. Treatment Options for Polycystic Ovary Syndrome International journal of women's health · 2011
    5. A Randomized Placebo-Controlled Study on the Effects of Pioglitazone on Cortisol Metabolism in Polycystic Ovary Syndrome Fertility and sterility · 2008
    6. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007

    Related research 1

    1. Polycystic Ovary Syndrome and Insulin-Resistant Hyperinsulinemia Journal of the American Academy of Dermatology · 2001