TLDR Exercise improves insulin sensitivity and hormone regulation in PCOS rats.
The study demonstrated that exercise activated the PI3K/AKT signaling pathway in PCOS rats by decreasing the expression of 5α-reductase type 1 (5αR1). Fifty-four female rats were divided into various groups, including sedentary and exercise groups, with some receiving 5α-reductase inhibitors. The results showed that the exercise group had significantly higher levels of Akt phosphorylation and PI3K p85 expression compared to the sedentary group, indicating improved insulin sensitivity and androgen regulation through the PI3K-Akt pathway.
20 citations,
March 2017 in “Reproductive Biology and Endocrinology” Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.
1514 citations,
December 2011 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
8 citations,
August 2011 in “Journal of Pharmacology and Experimental Therapeutics” Dosing time affects finasteride's effectiveness and safety in rats.
514 citations,
February 2011 in “International journal of women's health” Different treatments for PCOS focus on the specific symptoms, with weight loss and lifestyle changes being important.
24 citations,
April 2008 in “Fertility and sterility” Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.
195 citations,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
60 citations,
September 2001 in “Journal of the American Academy of Dermatology” Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
