Skin and Metabolic Syndrome: A Review of Possible Associations

    January 2021 in “ Journal of Research in Medical Sciences ”
    Neda Adibi, Reza M. Robati
    From the encyclopedia
    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

    Tretinoin →

    the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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    Studysummary This review examines the interplay between metabolic syndrome and dermatologic conditions and reports no clinical results, emphasizing the need for awareness of their interconnected impacts when managing inflammatory skin diseases. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviews the associations between various medications and metabolic syndrome. It states that glucocorticoid use is not linked with metabolic syndrome in rheumatoid arthritis patients. Early life antibiotic exposure can impact pancreatic islet development and metabolic regulation. The antibiotic minocycline can lessen severe hyperglycemia in lipodystrophy patients, and low dose doxycycline can enhance glycemic control, lipid profiles, and islet morphology and function. The document also explores the effects of other medications like isotretinoin, methotrexate, tacrolimus, cyclosporine, anti-TNF-α therapy, hydroxychloroquine, H1 antihistamine, and spironolactone on metabolic syndrome. For example, isotretinoin does not cause insulin resistance in acne patients, methotrexate therapy is associated with a reduced prevalence of metabolic syndrome in rheumatoid arthritis patients over 60, and spironolactone improves glucose and lipid metabolism by reducing hepatic steatosis and inflammation.
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