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    Glossary Flutamide

    nonsteroidal antiandrogen used to treat prostate cancer and hair loss

    Flutamide is a nonsteroidal antiandrogen medication primarily used to treat prostate cancer by blocking the action of androgens (male hormones) like testosterone. It can also be used off-label to manage conditions like hirsutism (excessive hair growth) and androgenic alopecia (pattern hair loss) by reducing the effects of androgens on hair follicles.

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    1. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial Fertility and Sterility · 1994 · 165 citations
    2. Effects of Flutamide and Finasteride on Rat Testicular Descent Endocrinology · 1991 · 143 citations
    3. Treatment of hirsutism with the pure antiandrogen flutamide Journal of the American Academy of Dermatology · 1990 · 130 citations
    4. Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients The American Journal of Medicine · 1992 · 116 citations
    5. A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999 · 113 citations
    6. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double Blind, Placebo-Controlled Trial1 The Journal of Clinical Endocrinology and Metabolism · 2000 · 94 citations
    7. Comparison of finasteride versus flutamide in the treatment of hirsutism European journal of endocrinology · 1999 · 75 citations
    8. Anti-Androgenicity of Flutamide and its Metabolite Sch 16423 Biochemical Society Transactions · 1979 · 72 citations
    9. A prospective, randomized trial comparing flutamide (250 mg/d) and finasteride (5 mg/d) in the treatment of hirsutism Fertility and Sterility · 2000 · 50 citations
    10. Tamoxifen for flutamide/finasteride-induced gynecomastia Urology · 1997 · 49 citations
    11. Hepatotoxicity Complicating Flutamide Treatment of Hirsutism Annals of internal medicine · 1993 · 43 citations
    12. Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia Drug Development and Industrial Pharmacy · 2015 · 42 citations
    13. Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss Annals of Pharmacotherapy · 2011 · 42 citations
    14. The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial Drug Design Development and Therapy · 2015 · 38 citations
    15. Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome Gynecological Endocrinology · 1997 · 38 citations
    16. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995 · 37 citations
    17. Clinical efficacy and safety of low‐dose flutamide alone and combined with an oral contraceptive for the treatment of idiopathic hirsutism Clinical endocrinology · 1995 · 36 citations
    18. Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism Fertility and Sterility · 1999 · 32 citations
    19. Treatment of female pattern hair loss with the androgen receptor antagonist flutamide Australasian Journal of Dermatology · 2011 · 30 citations
    20. Characteristics of flutamide action on prostatic and testicular functions in the rat Journal of Steroid Biochemistry · 1988 · 30 citations
    21. Hepatotoxicity with low- and ultralow-dose flutamide: a surveillance study on 203 hyperandrogenic young females Fertility and Sterility · 2012 · 29 citations
    22. Low-Dose Flutamide (125 mg/Day) as Maintenance Therapy in the Treatment of Hirsutism Hormone Research in Paediatrics · 2001 · 27 citations
    23. Flutamide in the treatment of hirsutism International journal of gynaecology and obstetrics · 1991 · 27 citations
    24. Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats Progress in Neuro-psychopharmacology & Biological Psychiatry · 1993 · 26 citations
    25. A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999 · 23 citations
    26. Treatment of hirsutism with flutamide and a low-dosage oral contraceptive in polycystic ovarian disease patients Fertility and sterility · 1994 · 20 citations
    27. Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation Journal of Chemical & Engineering Data · 2009 · 19 citations
    28. A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism Journal of Endocrinological Investigation · 2009 · 18 citations
    29. Successful Treatment of Hirsutism in HAIR-AN Syndrome Using Flutamide, Spironolactone, and Birth Control Therapy Archives of dermatology · 1997 · 17 citations
    30. Flutamide-Loaded Zein Nanocapsule Hydrogel, a Promising Dermal Delivery System for Pilosebaceous Unit Disorders Aaps Pharmscitech · 2018 · 10 citations