TLDR Flutamide combined with a low-dose birth control pill effectively reduces excessive hair growth in women with polycystic ovarian disease.
The study evaluated the effectiveness of flutamide combined with a low-dosage oral contraceptive (OC) in treating hirsutism in 22 women with polycystic ovarian disease (PCOD) who were unresponsive to OC treatment alone. Over 8 months, the Ferriman-Gallwey score, which measures hair density, significantly improved from 25.4 ± 3.96 to 14.6 ± 1.92. Hormonal assays showed that while plasma levels of total testosterone (T) and estradiol (E2) remained unchanged, levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), androstenedione (A), and dihydrotestosterone (DHT) decreased significantly. Additionally, sex hormone-binding globulin levels increased markedly. The study concluded that flutamide, when used with a low-dosage OC, effectively reduced hirsutism in PCOD patients unresponsive to OC treatment alone.
Cited in this study
4 / 4 results
165 citations
,
February 1994 in “Fertility and Sterility” Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
130 citations
,
September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
18 citations
,
August 1985 in “European journal of endocrinology” Cyproterone acetate is effective for treating hirsutism, but some patients may feel worse on low-dose maintenance therapy.
53 citations
,
January 1985 in “Acta obstetricia et gynecologica Scandinavica” Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.
1 citations
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October 1997 in “PubMed” Finasteride and flutamide can effectively treat hirsutism, with abdominal hairs showing the most sensitivity to the treatment.
36 citations
,
November 1995 in “Clinical endocrinology” Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.
165 citations
,
February 1994 in “Fertility and Sterility” Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
130 citations
,
September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
