TLDR Flutamide combined with a low-dose birth control pill effectively reduces excessive hair growth in women with polycystic ovarian disease.
The study evaluated the effectiveness of flutamide combined with a low-dosage oral contraceptive (OC) in treating hirsutism in 22 women with polycystic ovarian disease (PCOD) who were unresponsive to OC treatment alone. Over 8 months, the Ferriman-Gallwey score, which measures hair density, significantly improved from 25.4 ± 3.96 to 14.6 ± 1.92. Hormonal assays showed that while plasma levels of total testosterone (T) and estradiol (E2) remained unchanged, levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), androstenedione (A), and dihydrotestosterone (DHT) decreased significantly. Additionally, sex hormone-binding globulin levels increased markedly. The study concluded that flutamide, when used with a low-dosage OC, effectively reduced hirsutism in PCOD patients unresponsive to OC treatment alone.
165 citations,
February 1994 in “Fertility and Sterility” Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
130 citations,
September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
18 citations,
August 1985 in “European journal of endocrinology” Cyproterone acetate is effective for treating hirsutism, but some patients may feel worse on low-dose maintenance therapy.
53 citations,
January 1985 in “Acta obstetricia et gynecologica Scandinavica” Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.
1 citations,
October 1997 in “PubMed” Finasteride and flutamide can effectively treat hirsutism, with abdominal hairs showing the most sensitivity to the treatment.
36 citations,
November 1995 in “Clinical endocrinology” Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.
165 citations,
February 1994 in “Fertility and Sterility” Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.
130 citations,
September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
