October 2025 in “International Wound Journal” In a study using a rat model of hypertrophic scars, researchers found that gamma-irradiated human amniotic fluid improved wound healing, collagen remodelling, immune response, and scar characteristics more effectively than saline or non-irradiated amniotic fluid, indicating its potential for clinical applications in scar management.
In this study, perilla seed extract obtained through supercritical fluid extraction was found to promote hair follicle cell proliferation and downregulate key genes linked to androgenetic alopecia, showing potential as a natural treatment for hair loss in vitro.
July 2025 in “Journal of the Pakistan Medical Association” In this study, intralesional triamcinolone acetonide combined with 5-fluorouracil was more effective for treating keloids, showing a good to excellent response in 95% of cases and fewer side effects, compared to triamcinolone acetonide alone, which achieved a 70% response rate.
February 2025 in “Chemico-Biological Interactions” In this study, researchers investigated how 5-fluorouracil (5-FU) impacts hair follicle cells, finding that it delays hair growth by inhibiting angiogenesis and β-catenin signaling. This discovery could help develop treatments for chemotherapy-induced alopecia in cancer patients receiving 5-FU.
October 2024 in “Zagazig University Medical Journal” This clinical trial found that transdermal delivery of 5-Fluorouracil using fractional CO2 laser resulted in a significantly better treatment response in alopecia areata patients compared to intralesional injections of the same drug, with a greater reduction in the Severity of Alopecia Tool Score.
In this research, low-fluence light-based hair removal was explored, revealing its potential for at-home use with improvements in efficacy and safety, particularly for dark skin individuals, although further studies are necessary.
June 2024 in “Skin Research and Technology” In this study, researchers observed significant differences in microbial composition between UV-induced fluorescent and non-fluorescent scalp areas in patients with androgenetic alopecia, noting a higher abundance of Cutibacterium in the fluorescent regions.
April 2024 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal” This study at Al-Azhar University Hospitals found that combining a fractional CO2 laser or microneedling with topical 5-Fluorouracil (5-FU) is more effective and safe for treating vitiligo than using either treatment alone, offering a new therapeutic option for patients.
April 2024 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal” In this study, vitiligo patients treated with a combination of fractional CO2 laser or microneedling followed by topical 5-Fluorouracil experienced more effective and safe outcomes compared to using either method alone.
February 2024 in “Curēus” This case report describes an 83-year-old man who developed focal neurotoxicity, including paralysis and pain, in the area treated with topical 5-fluorouracil cream for actinic keratoses, suggesting a potential neurotoxic risk associated with the drug, especially in those with a specific genetic deficiency.
In this study, the SFE-4 extract from coffee pulp demonstrated potential effects for treating androgenetic alopecia by enhancing cell proliferation and gene expression related to hair growth pathways in vitro, using human hair follicle dermal papilla and prostate cancer cells.
September 2023 in “The Journal of Steroid Biochemistry and Molecular Biology” Stopping finasteride for male pattern hair loss changes neuroactive steroid levels in the brain and blood.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, freezing gamma-irradiated amniotic fluid increased hair follicles and accelerated the transition to the anagen stage in rats, suggesting potential for treating hair loss safely and effectively.
May 2023 in “Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy” This study developed a synchronized fluorescence spectroscopic approach to quantify finasteride and tadalafil in various forms, achieving high accuracy with %recoveries of about 99.62% and 100.19% respectively, and demonstrated superior environmental friendliness compared to previous methods.
This study found that dermoscopy combined with calcium fluorescent white staining effectively aided in the early diagnosis and treatment evaluation of tinea capitis by highlighting specific hair changes and fluorescent patterns associated with different dermatophyte infections in a sample of 20 patients.
This review summarizes evidence suggesting that the ratio of Myo-Inositol to D-Chiro-Inositol in follicular fluid is crucial for oocyte and embryo quality.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that using a commercially available IPL home-use device led to significant hair reduction and demonstrated long-term efficacy in maintaining hair reduction one year after treatment.
January 2012 in “Journal of Cosmetics Dermatological Sciences and Applications” This study found that iontophoresis significantly enhances the skin penetration of magnesium salt of L-ascorbic acid 2-phosphate, especially in hairy mice, compared to passive diffusion.
October 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study demonstrates that using a K15 promoter-driven GFP labeling technique allows for the identification and characterization of epithelial stem cells in adult human hair follicles.
This study found that certain concentrations of sodium fluoride accelerated apoptosis in cultured human hair follicles, while sodium selenite could counteract this toxicity in vitro.
74 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.
59 citations
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November 2018 in “Psychoneuroendocrinology” This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.
56 citations
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March 2017 in “Plant and Cell Physiology” This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.
50 citations
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January 2016 in “The Journal of Clinical Endocrinology and Metabolism” This study found that miRNA expression profiles in follicular fluid are altered in women with PCOS, with certain miRNAs potentially useful for distinguishing patient subtypes and contributing to understanding PCOS heterogeneity.
33 citations
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April 2011 in “Journal of Veterinary Internal Medicine” This study found that inhaled fluticasone for 11 months did not adversely affect the immune function or response to vaccination in horses with heaves.
32 citations
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December 2013 in “Biological & Pharmaceutical Bulletin” In this study, rice bran supercritical CO2 extract demonstrated potential to promote hair growth in mice, increasing hair follicles and growth factor expression, similarly to 3% minoxidil.
31 citations
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December 2002 in “Biochimica et biophysica acta. G, General subjects/Biochimica et biophysica acta. General subjects (Online)” This study identified two types of calcium in human scalp hair, with one type highly variable between individuals, potentially impacting the analysis of environmental and medical factors related to hair calcium.
22 citations
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August 2011 in “Journal of Supercritical Fluids” In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.
19 citations
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March 2017 in “Scientific Reports” This study suggests that the protease HAT-L4 plays a significant role in maintaining epidermal barrier function to prevent body fluid loss, as its absence in mice led to increased fluid loss and higher mortality.
11 citations
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March 2023 in “Frontiers in Nutrition” This study found that a modest increase in dietary zinc over six months resulted in a detectable increase in sulfur and zinc counts in individual hairs, suggesting a non-invasive method to monitor zinc intake effects.