Pooled, Frozen, Gamma-Irradiated Amniotic Fluid Enhances Histomorphological Remodeling in Hypertrophic Scars

    October 2025 in “ International Wound Journal ”
    Gamze Tümentemur, Elif Ganime Aygün, Bulut Yurtsever, Ercüment Ovalı
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    TLDR Gamma-irradiated amniotic fluid improves healing and reduces thickness of hypertrophic scars.
    This study explored the effects of pooled-frozen and pooled-frozen gamma-irradiated human amniotic fluid (hAF) on hypertrophic scars in 15 adult male Sprague–Dawley rats. The rats received subcutaneous injections of either saline, pooled-frozen hAF, or pooled-frozen gamma-irradiated hAF. After 21 days, both hAF treatments significantly improved wound healing compared to the control, with the gamma-irradiated group showing superior results. This group exhibited enhanced granulation tissue formation, better collagen remodelling, increased M2 macrophage density, improved reepithelialisation, higher hair follicle density, and reduced scar thickness. These findings suggest that gamma-irradiated hAF could be a more effective and minimally invasive treatment for hypertrophic scars, with potential for clinical application.
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