Comparison of Intralesional Triamcinolone Acetonide Alone and With 5-Fluorouracil for the Treatment of Keloids
July 2025
in “
Journal of the Pakistan Medical Association
”
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Studysummary In this study, intralesional triamcinolone acetonide combined with 5-fluorouracil was more effective for treating keloids, showing a good to excellent response in 95% of cases and fewer side effects, compared to triamcinolone acetonide alone, which achieved a 70% response rate. Our plain-language summary of this paper — not a Tressless recommendation.
The study involving 66 patients compared the efficacy of intralesional triamcinolone acetonide (TCA) alone versus in combination with 5-fluorouracil (5-FU) for treating keloids. Group B, which received the combination treatment, showed a 95% good to excellent response rate, outperforming Group A's 70% response with TCA alone. The combination therapy also resulted in fewer side effects, such as atrophy and telangiectasia, and demonstrated a faster response. At a 6-month follow-up, no recurrence or serious side effects were noted, indicating that the combination of TCA and 5-FU is a more effective and safer option for keloid treatment.
