Apoptotic Study on the Effect of Fluorine and Selenium on the Human Hair Follicle In Vitro
January 2007
in “
PubMed
”
Studysummary This study found that certain concentrations of sodium fluoride accelerated apoptosis in cultured human hair follicles, while sodium selenite could counteract this toxicity in vitro. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the effects of fluorine and selenium on human hair follicle apoptosis in vitro. It was found that sodium fluoride at concentrations of 1 mmol/L and 10 mmol/L increased apoptotic cells in various parts of the hair follicle by the 5th day of culture. However, the addition of 0.01 mmol/L sodium selenite reduced the toxicity of 1 mmol/L sodium fluoride, particularly in the outer root sheath and hair bulb. This indicated that sodium fluoride could accelerate hair follicle apoptosis, while sodium selenite could mitigate its toxic effects.
