Enhanced Iontophoretic Delivery of Magnesium Ascorbyl 2-Phosphate and Sodium Fluorescein to Hairless and Hairy Mouse Skin

The study demonstrated that iontophoresis significantly enhanced the penetration of magnesium ascorbyl 2-phosphate (APMg) into mouse skin, particularly in hairy mice, where penetration increased 3 to 8 times compared to 1.5 to 2.5 times in hairless mice. This method, using a cathode, facilitated the transfollicular pathway more effectively than passive diffusion or the transdermal pathway. The iontophoretic delivery was also tested with sodium fluorescein, confirming the enhanced penetration in vivo. The effectiveness of iontophoretic enhancement was influenced by factors such as current density and application duration.