Scanning Electrochemical Microscopy of Iontophoretic Transport in Hairless Mouse Skin: Analysis of the Relative Contributions of Diffusion, Migration, and Electroosmosis to Transport in Hair Follicles

    December 2000 in “ Journal of Pharmaceutical Sciences ”
    Bradley D. Bath, Erik R. Scott, J. Bradley Phipps, Henry S. White
    TLDR Hair follicles significantly enhance electroosmotic transport during iontophoresis.
    The study used scanning electrochemical microscopy (SECM) to investigate the transport mechanisms in hairless mouse skin, particularly focusing on hair follicles. By applying an electric current, the researchers examined the transport of an anion, a cation, and a neutral molecule to understand the contributions of diffusion, migration, and electroosmosis. They discovered that hair follicles possess a net negative charge at neutral pH, which facilitated electroosmotic transport, increasing the rate of neutral molecule transport by 2.4 times at 0.1 mA/cm². Migration notably enhanced the flux of charged species. The electroosmotic flow velocity was measured at 0.5 μm/s at 0.1 mA/cm², with a net volume flow rate of 0.3 μL/cm²h. The study concluded that hair follicles are a crucial pathway for electroosmotic flow during iontophoresis, with follicle openings averaging 21 ± 5 μm in radius.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 13 results

      community Red light therapy - research says they work, reviews say they don't - Turns out commercial device are severely under-powered, so could this actually work?

      in Technology  76 upvotes 1 year ago
      The conversation discusses the effectiveness of commercial Low-Level Laser Therapy (LLLT) devices for hair growth, suggesting they are underpowered compared to the ideal energy output shown in medical research. A user plans to build a custom helmet that meets the required specifications for effective treatment.

      community Horrible news, Stemson Therapeutics has shut down

      in Technology  193 upvotes 1 week ago
      Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Finasteride is Good for Heart Health!

      in Research/Science  119 upvotes 10 months ago
      Finasteride, a hair loss and prostate drug, may also benefit heart health. Some users discuss the potential negative effects of DHT on the heart and the balance between hair loss treatments and heart health.

    Similar Research

    5 / 1000+ results