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Glossary Diffusion

movement of molecules from high to low concentration areas

Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration until they are evenly distributed. In biological contexts, this is crucial for the transport of nutrients, gases, and waste products across cell membranes, ensuring that cells function properly.

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Research

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research Scanning Electrochemical Microscopy of Iontophoretic Transport in Hairless Mouse Skin. Analysis of the Relative Contributions of Diffusion, Migration, and Electroosmosis to Transport in Hair Follicles

50 citations , December 2000 in “Journal of Pharmaceutical Sciences”

This study found that electroosmotic flow through hair follicles significantly contributes to solution flow during iontophoresis in hairless mouse skin.

research Transdermal finasteride delivery via powder-carrying microneedles with a diffusion enhancer to treat androgenetic alopecia

33 citations , November 2019 in “Journal of Controlled Release”

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

research Diffusion properties of model compounds in artificial sebum

29 citations , May 2007 in “International journal of pharmaceutics”

This study found that drug transport through artificial sebum varies depending on the compound, suggesting that sebum-targeted delivery can be optimized by selecting compounds based on their distinct transport profiles in sebum versus skin.

research Kinetics and Equilibrium of Solute Diffusion into Human Hair

8 citations , July 2012 in “Annals of biomedical engineering”

This study found that the uptake of molecules by hair is influenced by both hydrophobic and ionic charge interactions, with binding affinity decreasing as pH approaches the solute's dissociation constant.

research Determination of Solute Diffusion Properties in Artificial Sebum

6 citations , May 2019 in “Journal of pharmaceutical sciences”

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

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community Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

4 upvotes 1 year ago

Minoxidil can be effectively delivered through nanoemulsions containing eucalyptol or oleic acid, enhancing its diffusivity and targeting hair follicles. This contradicts the advice against mixing minoxidil with oils in topical formulations.

community 7 month progress. From a slap head to a forehead. (32M)

52 upvotes 8 months ago

A 32-year-old male shares his 7-month hair regrowth progress using 1 mg finasteride daily, 5% minoxidil twice daily, dermarolling every four days, 1.5% ketoconazole shampoo every three days, and zinc and vitamin D supplements initially. He applies minoxidil primarily to his temples and hairline, avoiding the crown, and reports significant improvement in diffusive thinning.

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