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GlossaryFluorescence Recovery After Photobleaching

technique to study molecular movement by observing fluorescence recovery

Fluorescence Recovery After Photobleaching (FRAP) is a technique used to study the movement and behavior of molecules within living cells. In this method, a specific region of a fluorescently labeled sample is intentionally bleached with intense light, and the recovery of fluorescence in that area is monitored over time. This helps researchers understand the dynamics of molecular diffusion, binding interactions, and cellular processes.

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Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function

research Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function

31 citations, July 2004 in “Molecular Medicine”

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

research A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model

September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

The mTurq2-Col4a1 mouse model shows that cells can divide while attached to stable basement membranes during development.

research Celsr1 And Celsr2 Exhibit Distinct Adhesive Interactions And Contributions To Planar Cell Polarity

7 citations, January 2023 in “Frontiers in cell and developmental biology”

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

research Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 246 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Topical Fin Vs Oral Fin. Which is better and has less sides?

in Finasteride/Dutasteride 45 upvotes 1 year ago

Comparing the effectiveness and side effects of topical finasteride versus oral finasteride, with people sharing their experiences using both treatments to manage hair loss.

community 4 years on finasteride and Minoxidil with great success. Ask me stuff!

in Progress Pictures 954 upvotes 2 years ago

. ummwhatsure: No it doesn't. I started losing my hair around 27/28. This user has had great success with a combination of finasteride and Minoxidil, taking 1 milligram of finasteride per day and applying Minoxidil twice daily for 4 years, starting when they were 31. They experienced some shedding in the first two years, but now have thicker, fuller hair than before.