The Transmembrane Serine Protease HAT-Like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss

    March 2017 in “ Scientific Reports ”
    Zhiwei Zhang, Yae Hu, Ruhong Yan … Qingyu Wu
    Studysummary This study suggests that the protease HAT-L4 plays a significant role in maintaining epidermal barrier function to prevent body fluid loss, as its absence in mice led to increased fluid loss and higher mortality.
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    Research cited in this study 4

    1. Autosomal Recessive Ichthyosis With Hypotrichosis Syndrome: Further Delineation Of The Phenotype Clinical Genetics · 2008
    2. Autosomal Ichthyosis With Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007
    3. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    4. Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis Oncogene · 2002