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Did you mean Transmembrane Protease Serine 2?

GlossaryTMPRSS2 (Transmembrane Protease Serine 2)

enzyme aiding viral entry into human cells

TMPRSS2 stands for Transmembrane Serine Protease 2, an enzyme that plays a role in the activation of certain proteins by cutting them at specific sites. It is notably involved in the process by which the SARS-CoV-2 virus, responsible for COVID-19, enters human cells, making it a target for therapeutic interventions.

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research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

137 citations, October 2009 in “The American journal of pathology”

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

research Androgenetic Alopecia as a Complication of SARS-CoV-2 Infection

April 2022 in “Brazilian Medical Students”

People with androgenetic alopecia may have a higher risk of severe COVID-19.

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

9 citations, September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

research A Novel Mutation in ST14 at a Functionally Significant Amino Acid Residue Expands the Spectrum of Ichthyosis-Hypotrichosis Syndrome

11 citations, December 2017 in “Orphanet Journal of Rare Diseases”

A new mutation in the ST14 gene broadens the understanding of ichthyosis-hypotrichosis syndrome.

research Targeting Host Cell Proteases as a Potential Treatment Strategy to Limit the Spread of SARS-CoV-2 in the Respiratory Tract

15 citations, December 2020 in “Pharmacology Research & Perspectives”

Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.

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