April 2024 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal” In this study, vitiligo patients treated with a combination of fractional CO2 laser or microneedling followed by topical 5-Fluorouracil experienced more effective and safe outcomes compared to using either method alone.
16 citations
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January 2023 in “Journal of Cosmetic Dermatology” This study found that micro-needling combined with topical 5-fluorouracil (5-FU) was more effective in treating vitiligo patches than topical tacrolimus, with significant improvement observed in six patients, although it caused mild side effects like erythema and irritation.
October 2024 in “Zagazig University Medical Journal” This clinical trial found that transdermal delivery of 5-Fluorouracil using fractional CO2 laser resulted in a significantly better treatment response in alopecia areata patients compared to intralesional injections of the same drug, with a greater reduction in the Severity of Alopecia Tool Score.
In this study involving 13 patients with vitiligo-associated leukotrichia, minimal hair repigmentation was observed following treatment with fractional CO₂ laser and topical betamethasone, though the method was well tolerated, highlighting the need for further research to optimize treatment parameters.
3 citations
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January 2023 in “Journal of Cosmetic Dermatology” This study found that combining Fractional CO2 laser with platelet-rich plasma led to better improvement in vitiligo treatment compared to platelet-rich plasma alone, based on patient satisfaction and lesion size reduction.