Fractional CO2 Laser Versus Microneedling Followed by Topical 5-Fluorouracil in the Treatment of Non-Segmental Vitiligo

April 2024 in “ Al-Azhar International Medical Journal /Al-Azhar International Medical Journal ”

Essam Bakr Abdel Aal, Sameh Fahmy, Hassan Abdalla Hassan Kandil

fractional CO2 laser microneedling 5 Fluorouracil 5-FU non-segmental vitiligo CO2 laser

TLDR Combining fractional CO2 laser or microneedling with 5-FU is more effective and safer for treating vitiligo.

This study compared the effectiveness of two treatments for non-segmental vitiligo in 30 patients: fractional CO2 laser followed by topical 5 Fluorouracil (5-FU) and microneedling followed by 5-FU. The results indicated that combining either fractional CO2 laser or microneedling with 5-FU is more effective and safer than using either treatment alone. This combination offers a new therapeutic approach for vitiligo, providing a beneficial treatment option for patients.

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