3 citations
,
March 2024 in “Journal of the American Academy of Dermatology” Low-dose naltrexone helps improve symptoms and stabilize frontal fibrosing alopecia and lichen planopilaris.
31 citations
,
December 2016 in “Anais Brasileiros de Dermatologia” This review discusses the fibrogenic effects of TGFβ1, the regulatory role of PPAR, and the potential involvement of DHEA in frontal fibrosing alopecia, but reports no new clinical results.
31 citations
,
January 2016 in “Skin Appendage Disorders” This study observed two cases of frontal fibrosing alopecia developing on preexisting vitiligo, suggesting a potential causal link between the two conditions.
22 citations
,
April 2013 in “International Journal of Dermatology” Frontal fibrosing alopecia can occur with lichen planus pigmentosus, needing careful diagnosis and treatment.
10 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found a high prevalence of genital Lichen sclerosus and autoimmune comorbidities in patients with frontal fibrosing alopecia, suggesting a possible shared autoimmune process.
3 citations
,
October 2021 in “Journal of Cosmetic Dermatology” This review discusses the characteristic trichoscopy patterns useful in differentiating lichen planopilaris and frontal fibrosing alopecia from similar conditions but reports no new clinical results.
2 citations
,
July 2025 in “Journal of the European Academy of Dermatology and Venereology” This study involved 69 hair experts using a Delphi process to achieve consensus on treating frontal fibrosing alopecia, finding strong agreement on disease monitoring but less on physical and systemic therapies, indicating the need for more research.
June 2023 in “Brazilian Journal of Case Reports” In this case report, a patient with early-stage Frontal Fibrosing Alopecia showed substantial improvement in follicular density and inflammation control after three monthly sessions of Botulinum Toxin Type A administered via microinfusion.
September 2021 in “CRC Press eBooks” This review discusses fibrosing alopecia in a pattern distribution and highlights diagnostic features, but reports no new clinical results; the authors emphasize the value of trichoscopy and histology in diagnosis.
May 2025 in “Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)” This study found that using platelet-rich plasma in optimal doses improves mesh integration and reduces the risk of chronic pain and fibrosis in hernia repair, but overdoses led to inflammatory complications in rats.
29 citations
,
June 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery” This review outlines the mechanisms, clinical features, and management strategies for alopecia areata and presents no new experimental findings.
March 2017 in “The American Journal of Cosmetic Surgery” This case report suggests that transplanted hair follicles may be more resistant to alopecia areata than native hair, potentially offering new insights into the condition's pathophysiology and treatment options.
42 citations
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June 2009 in “Journal of Cosmetic Dermatology” In this study, researchers observed that follicular microinflammation significantly contributes to the early stages of male androgenetic alopecia, potentially leading to perifollicular fibrosis and follicle destruction as the condition progresses.
13 citations
,
January 2020 in “Scientific Reports” This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.
January 1976 in “Revista de Estudios Agrosociales” This study suggests a potential causal link between frontal fibrosing alopecia and vitiligo, as observed in two cases where the conditions co-occurred on preexisting vitiligo of the forehead.
17 citations
,
July 2018 in “International Journal of Cosmetic Science” This study found that keratin-based particles were able to recover and enhance the mechanical properties and thermal stability of virgin and overbleached Asian hair, improving its strength and smoothness by around 40%, and demonstrated safety in human skin keratinocytes.
January 2026 in “Frontiers in Medicine” This article questions whether frontal fibrosing alopecia and fibrosing androgeneic patterned hair loss are overlapping conditions or stages of the same process, calling for further research to clarify their underlying factors.
3 citations
,
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found that inhibiting YAP signaling in skin wounds leads to regenerative repair with active Trps1 and Wnt signaling, contrasting the typical fibrotic scarring process.
In this study, researchers used a mouse model to identify an adipocyte-to-fibroblast conversion pathway that promotes mast-cell recruitment and dermal fibrosis in atopic dermatitis, suggesting a potential therapeutic approach to block this process and reduce inflammation and fibrosis.
May 2023 in “ACS Biomaterials Science & Engineering” This study found that a silk fibroin/sodium alginate scaffold effectively delivers human umbilical mesenchymal stem cells to promote scarless wound healing and hair follicle regeneration in vivo by inducing specific cellular processes and mitigating endoplasmic reticulum stress.
February 2021 in “Journal of The American Academy of Dermatology” This study observed that fibrosis occurs in the bulge region of hair follicles affected by androgenetic alopecia and is correlated with the hair miniaturization process.
January 2022 in “Дерматологія та венерологія” This paper presents two cases of frontal fibrosing alopecia in postmenopausal women, noting challenges in monitoring due to the invasive nature of the diagnostic process.
April 2024 in “Authorea (Authorea)” This review summarizes techniques like Raman spectroscopy, nanoindentation, and small-angle X-ray scattering to explore the biophysical interactions in collagen fibers, aiming to enhance understanding of fibroblast behavior and mechanisms involved in organ fibrosis and healing processes.
44 citations
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January 2006 in “Biological & Pharmaceutical Bulletin” This research suggests that testosterone-induced expression of TGF-beta1 and type I procollagen may lead to perifollicular fibrosis in androgenetic alopecia, with finasteride inhibiting this process as a possible mechanism for its effects.
September 2019 in “Romanian Journal of Pediatrics” This article discusses the unique regenerative healing process in fetal skin that can occur without scarring, highlighting potential therapeutic targets to reduce fibrosis in postnatal wound healing.
733 citations
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September 2009 in “Journal of Cell Science” This article reviews the complex process of wound repair, emphasizing recent microarray studies and proteomic analyses, but reports no new clinical results.
2 citations
,
September 2023 in “Frontiers in molecular biosciences” This review highlights the potential of targeting hepatic stellate cell ferroptosis as a treatment strategy for liver fibrosis, underscoring the need for further research into ferroptosis mechanisms in these cells to better understand and combat this condition.
August 2023 in “International Journal of Molecular Sciences” This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.
66 citations
,
July 2015 in “Organogenesis” This review summarizes recent findings on how Wnt signaling proteins play crucial roles in the cutaneous wound healing process but reports no new clinical results.
33 citations
,
September 2020 in “Current Rheumatology Reports” This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.