Recalcitrant Lichen Planopilaris and Frontal Fibrosing Alopecia Responding to Tildrakizumab

May 2020 in “ Dermatologic therapy ”

Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair

lichen planopilaris frontal fibrosing alopecia tildrakizumab interleukin-23 monoclonal antibody cicatricial alopecia

TLDR Tildrakizumab significantly improved recalcitrant lichen planopilaris and frontal fibrosing alopecia.

The paper reported a case of recalcitrant lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) that showed significant clinical improvement after four doses of tildrakizumab, an interleukin-23 monoclonal antibody. LPP and FFA are types of lymphocytic, cicatricial alopecias, with LPP presenting as multifocal patchy alopecia and FFA causing hairline recession. The treatment aimed to arrest the inflammatory process, which is often challenging and yields variable responses.

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Research cited in this study

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FFA is more common in postmenopausal women, can affect younger women, and may stabilize over time.

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Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

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