Recalcitrant Lichen Planopilaris and Frontal Fibrosing Alopecia Responding to Tildrakizumab

May 2020 in “ Dermatologic therapy ”

Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair

lichen planopilaris frontal fibrosing alopecia tildrakizumab interleukin-23 monoclonal antibody cicatricial alopecia

TLDR Tildrakizumab significantly improved recalcitrant lichen planopilaris and frontal fibrosing alopecia.

The paper reported a case of recalcitrant lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) that showed significant clinical improvement after four doses of tildrakizumab, an interleukin-23 monoclonal antibody. LPP and FFA are types of lymphocytic, cicatricial alopecias, with LPP presenting as multifocal patchy alopecia and FFA causing hairline recession. The treatment aimed to arrest the inflammatory process, which is often challenging and yields variable responses.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations, January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research Single-Center Analysis of Patients with Frontal Fibrosing Alopecia: Evidence for Hypothyroidism and a Good Quality of Life

9 citations, October 2018 in “Journal of international medical research”

Frontal fibrosing alopecia is linked to hypothyroidism but doesn't affect quality of life.

research Sunscreen and Facial Skincare Products in Frontal Fibrosing Alopecia: A Case-Control Study

26 citations, October 2018 in “British Journal of Dermatology”

Regular use of sunscreen may be linked to frontal fibrosing alopecia.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations, March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

research Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis

155 citations, September 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

FFA is more common in postmenopausal women, can affect younger women, and may stabilize over time.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations, December 2004 in “Journal of The American Academy of Dermatology”

Some postmenopausal women with frontal fibrosing alopecia stopped losing hair with finasteride treatment, hinting at a possible hormonal cause.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations, January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

Related Community Posts Join

6 / 65 results

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 1 year ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 40 upvotes 6 months ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 6 months ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 8 months ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community 9 months on Fin - no progress , should I get on Dutasteride?

in Chat 10 upvotes 10 months ago

The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.