Recalcitrant Lichen Planopilaris and Frontal Fibrosing Alopecia Responding to Tildrakizumab

May 2020 in “ Dermatologic therapy ”

Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair

lichen planopilaris frontal fibrosing alopecia tildrakizumab interleukin-23 monoclonal antibody cicatricial alopecia

Studysummary In this study, a patient with recalcitrant lichen planopilaris and frontal fibrosing alopecia showed significant improvement after receiving four doses of the interleukin-23 monoclonal antibody tildrakizumab. Our plain-language summary of this paper — not a Tressless recommendation.

The paper reported a case of recalcitrant lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) that showed significant clinical improvement after four doses of tildrakizumab, an interleukin-23 monoclonal antibody. LPP and FFA are types of lymphocytic, cicatricial alopecias, with LPP presenting as multifocal patchy alopecia and FFA causing hairline recession. The treatment aimed to arrest the inflammatory process, which is often challenging and yields variable responses.

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research Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

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This study identified significant genetic associations with frontal fibrosing alopecia at four genomic loci, suggesting it is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07: 02 allele.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

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This review discusses the potential causes and treatments for frontal fibrosing alopecia but reports no new clinical findings, highlighting the need for further research to understand its pathogenesis and develop validated treatments.

research Single-Center Analysis of Patients with Frontal Fibrosing Alopecia: Evidence for Hypothyroidism and a Good Quality of Life

9 citations , October 2018 in “Journal of international medical research”

This study found no correlation between the extent of frontal fibrosing alopecia and quality of life, but observed a strong association with thyroid disease in affected women.

research Sunscreen and Facial Skincare Products in Frontal Fibrosing Alopecia: A Case-Control Study

26 citations , October 2018 in “British Journal of Dermatology”

This study found that high frequency use of sunscreen is associated with frontal fibrosing alopecia among women attending a specialist hair clinic in Australia.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations , March 2013 in “Journal of the European Academy of Dermatology and Venereology”

This study reported that while no effective treatment exists for frontal fibrosing alopecia, oral 5-alpha-reductase inhibitors showed the most promise, inducing a good clinical response in 45% of patients.

research Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis

155 citations , September 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations , December 2004 in “Journal of The American Academy of Dermatology”

This study observed that frontal fibrosing alopecia in postmenopausal women involves selective follicular inflammation, and finasteride treatment may slow disease progression, suggesting a potential androgen-related component.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.