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In this research, preclinical and early clinical studies on exosomes indicate their potential to modulate wound healing, skin rejuvenation, and hair growth in facial plastic surgery, but these treatments remain experimental until receiving FDA approval and robust clinical validation.

This case report observed that treatment with human placental mesenchymal stromal cell-derived exosome-enriched extracellular vesicles may improve symptoms of chronic cutaneous graft-versus-host disease, including hyperpigmentation and skin ulcers, in a patient resistant to conventional therapies.

This study reported severe and persistent skin reactions, including inflammation and scarring, after intradermal injections of unregulated exosome-based products, highlighting potential risks in aesthetic dermatology.

This study reviews the roles and mechanisms of MSC-derived exosomes in wound healing, noting their potential as promising cell-free therapies for cutaneous regeneration.

This narrative review synthesizes findings suggesting that exosomes show promise for dermatological and regenerative applications, with early human studies indicating acceptable safety and potential benefits for wound care, rejuvenation, and alopecia, though clinical and regulatory development is still in its infancy.

This review explores how exosomes can be used therapeutically in autoimmune skin diseases, emphasizing that their properties like stability and biocompatibility make them promising for targeting immune signaling pathways involved in conditions such as inflammation and scleroderma.

This study evaluated the effects of exosome therapy from hypoxia-treated mesenchymal stem cells on a fluconazole-induced alopecia model in rats and found that it significantly reduced TNF-α and increased VEGF levels, suggesting potential as a novel regenerative treatment for alopecia.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This study found that dendritic epidermal T cells and their exosomes enhance epidermal stem cell proliferation, accelerating wound re-epithelialization in the skin.

In this study, post-treatment with DCO was found to speed up epidermal wound healing after micro-needling of 3D skin models while maintaining the treatment's immunostimulatory benefits, potentially optimizing aftercare and reducing patient recovery time.

This study reviewed current scientific evidence on the use of exosomes for treating alopecias, finding they may stimulate dermal papilla cell proliferation and modulate inflammation, though challenges in standardization and long-term efficacy remain.

In this study, researchers engineered extracellular vesicles enriched with functional mitochondria to enhance healing in diabetic wounds by reversing mitochondrial and immunometabolic dysfunction in macrophages.

This literature review discusses exosomes' potential as biomarkers and therapeutics for skin issues, hair loss, and wound healing, but notes that their full functions and standardized applications remain inadequately understood.

In this case report, combining iontophoresis with exosomes was associated with increased hair density, improved hair quality, and reduced scalp inflammation in patients with female androgenetic alopecia.

In a rat skin wound model, this study observed that a composite dressing using chitosan hydrogel and exosomes derived from adipose mesenchymal stem cells enhanced wound healing by promoting collagen deposition, angiogenesis, and regeneration of hair follicle structures.

This review synthesizes recent research on exosomes, highlighting their role as key modulators in regenerative outcomes and suggesting they may offer advantages over stem cell-based therapies in process and regulation.

This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.

This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.

The researchers presented a case study on Exo.Reset®, a cosmetic formulation using extracellular vesicle technology, demonstrating systematic application of recognized standards to ensure scientific rigor and regulatory compliance in skin rejuvenation product development, providing a practical model for EV-based cosmetic innovations.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

This chapter highlights the potential of exosomes as innovative agents in cosmetic dermatology, noting their ability to promote skin rejuvenation and target issues like wrinkles, photoaging, and hair loss.

This meta-analysis found that ADSC-Exo therapy can enhance healing in both general and diabetic wounds by promoting neovascularization, improving epithelization and collagen fiber deposition, and reducing scar formation, suggesting significant potential for clinical and research applications.

In this systematic review and meta-analysis, researchers found that exosome therapies significantly improved facial wrinkles by 20.2% and enhanced hair density and thickness by 23.6% and 18%, respectively, despite challenges in generalizability due to study heterogeneity and nonstandardized protocols.

This review suggests that exosomes have potential as effective carriers for treating skin conditions like psoriasis, acne, eczema, and skin cancer by delivering therapeutic agents while minimizing side effects; the authors discuss their composition, uptake mechanisms, and clinical applications.

This review discusses the potential role of exosomes in aesthetic medicine for skin rejuvenation and hair restoration, but reports no new clinical findings and emphasizes the need for further studies with regulatory oversight.

This study developed a novel regenerative platform using nanozyme-enabled materials combined with exosomes and laser stimulation to enhance wound healing in a mouse model, which more effectively regulated reactive oxygen species and improved early angiogenesis and collagen organization compared to conventional methods.