Exosomes: Cutting-Edge Therapies for Autoimmune Dermatologic Diseases

    Reyhaneh Yarmohammadi, Kimia Didehvar, Jessika Cristina de Lima Ferreira, Saeideh Hatami, Dorsa Bahrami Zanjanbar, Negin Kamali, Naser Amini
    TLDR Exosomes show promise as effective treatments for autoimmune skin diseases with fewer side effects.
    Exosomes, small extracellular vesicles containing bioactive substances, are emerging as promising therapeutic tools for autoimmune dermatologic diseases due to their ability to influence immune signaling, inflammation, and tissue repair. This review highlights their potential in targeting autoimmune skin diseases, such as scleroderma, melanoma, and hair loss, by delivering treatments directly to targeted cells, thus minimizing side effects and enhancing treatment efficacy. Current medications for autoimmune diseases often have adverse reactions and limited efficacy, making exosomes an attractive alternative due to their stability, biocompatibility, and ability to evade the host immune system. The review emphasizes the novel role of exosomes in clinical applications for dermatological conditions.
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