Exosome Therapy from Hypoxia-Treated Mesenchymal Stem Cells Reduces TNF-α and Increases VEGF Levels in Fluconazole-Induced Alopecia Model

    November 2025 in “ Molecular and Cellular Biomedical Sciences ”
    Siska Marlina Sulistami, Sri Priyantini Mulyani, Agung Putra, Eko Setiawan
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    TLDR Exosome therapy from treated stem cells may help reduce inflammation and promote hair regrowth in alopecia.
    The study investigates the effects of exosome therapy from hypoxia-treated mesenchymal stem cells (Hypo-Exo MSCs) on TNF-α and VEGF levels in a fluconazole-induced alopecia model using 30 male Wistar rats. Results show that Hypo-Exo MSCs significantly reduced TNF-α levels and increased VEGF levels, with the 200 μg/mL Hypo-Exo MSCs-treated group showing the most pronounced effects. These findings suggest that Hypo-Exo MSCs could be a promising regenerative therapy for alopecia by modulating inflammation and promoting hair regrowth.
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