Exosome Therapy from Hypoxia-Treated Mesenchymal Stem Cells Reduces TNF-α and Increases VEGF Levels in Fluconazole-Induced Alopecia Model

    November 2025 in “ Molecular and Cellular Biomedical Sciences ”
    Siska Marlina Sulistami, Sri Priyantini Mulyani, Agung Putra, Eko Setiawan
    TLDR Exosome therapy from treated stem cells may help reduce inflammation and promote hair regrowth in alopecia.
    The study investigates the effects of exosome therapy from hypoxia-treated mesenchymal stem cells (Hypo-Exo MSCs) on TNF-α and VEGF levels in a fluconazole-induced alopecia model using 30 male Wistar rats. Results show that Hypo-Exo MSCs significantly reduced TNF-α levels and increased VEGF levels, with the 200 μg/mL Hypo-Exo MSCs-treated group showing the most pronounced effects. These findings suggest that Hypo-Exo MSCs could be a promising regenerative therapy for alopecia by modulating inflammation and promoting hair regrowth.
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      in Research/Science  5 upvotes 2 years ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

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      in Treatment  1 upvotes 1 year ago
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      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 1 year ago
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