Human Placental Mesenchymal Stromal Cell-Derived Exosome-Enriched Extracellular Vesicles for Chronic Cutaneous Graft-Versus-Host Disease: A Case Report

    December 2021 in “ Journal of Cellular and Molecular Medicine ”
    Amir Hossein Norooznezhad, Reza Yarani, Mehrdad Payandeh, Zohreh Hoseinkhani, Sarah Kiani, Elham Taghizadeh, Avnesh S. Thakor, Kamran Mansouri
    TLDR Exosome-enriched vesicles from placental cells improved skin condition in a patient with chronic graft-versus-host disease.
    This case report details the treatment of a 39-year-old male with chronic cutaneous graft-versus-host disease (cGVHD) using exosome-enriched extracellular vesicles (EVs) derived from human placental mesenchymal stromal cells (hPMSCs). The patient, unresponsive to conventional treatments, showed significant clinical improvements after four weekly EV treatments, including reduced hyperpigmentation, fewer and less severe ulcers, and better skin condition. Monocyte levels decreased from 18% to 5%, and no side effects were observed. The improvements lasted for 5 months post-treatment, suggesting hPMSC-derived EVs as a potential therapy for cGVHD, warranting further research.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 128 results

      community Did anyone tried exosome therapy

      in Treatment  1 upvotes 1 month ago
      Exosome therapy for hair loss is questioned for its effectiveness and authenticity. Users express skepticism, citing manipulated photos and high costs.

      community Anyone heard of Exosome stem cell treatment?

      in Treatment  1 upvotes 1 month ago
      Exosome stem cell treatment for hair loss, which is expensive and reportedly effective, but its popularity has declined. The conversation also mentions Minoxidil, finasteride, and RU58841 as treatments.

      community How do exosome injections for Hair Growth work?

      in Is this regrowth?  1 upvotes 1 year ago
      Exosome injections stimulate hair growth by using exosomes' healing potential to awaken dormant hair follicles and promote new hair cell creation. The procedure increases scalp blood circulation, encourages collagen and elastin formation, and regenerates hair follicles, improving hair thickness and quality.

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 1 year ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

    Similar Research

    5 / 675 results