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GlossaryChronic Graft-Versus-Host Disease (cGVHD)

condition where transplanted cells attack recipient's body long-term

Chronic Graft-Versus-Host Disease (cGVHD) is a condition that can occur after a stem cell or bone marrow transplant, where the donated cells (the graft) attack the recipient's body (the host). This immune response can lead to long-term complications affecting various organs, including the skin, liver, and gastrointestinal tract, and can manifest as rashes, liver dysfunction, and digestive issues.

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research Establishment of a Murine Chronic Graft-Versus-Host Disease Model with Scleroderma

January 2011 in “Junshi yixue”

A mouse model for studying scleroderma in chronic graft-versus-host disease was successfully created.

research Chronic Graft Versus Host Disease and Skin

32 citations , August 2003 in “Journal of the European Academy of Dermatology and Venereology”

cGVHD often severely affects the skin, causing rapid aging and other issues.

High Frequency of Cutaneous Manifestations Including Vitiligo and Alopecia Areata in a Prospective Cohort of Patients with Chronic Graft-Versus-Host Disease

research High Frequency of Cutaneous Manifestations Including Vitiligo and Alopecia Areata in a Prospective Cohort of Patients with Chronic Graft-Versus-Host Disease

17 citations , June 2016 in “Croatian Medical Journal”

Patients with chronic graft-versus-host disease often have skin problems like vitiligo and alopecia areata.

research Human Placental Mesenchymal Stromal Cell-Derived Exosome-Enriched Extracellular Vesicles for Chronic Cutaneous Graft-Versus-Host Disease: A Case Report

13 citations , December 2021 in “Journal of Cellular and Molecular Medicine”

Exosome-enriched vesicles from placental cells improved skin condition in a patient with chronic graft-versus-host disease.

research Non-Malignant Late Cutaneous Changes After Allogeneic Hematopoietic Stem Cell Transplant in Children

7 citations , March 2018 in “Journal of The American Academy of Dermatology”

Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.

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