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GlossaryChronic Graft-Versus-Host Disease (cGVHD)

condition where transplanted cells attack recipient's body long-term

Chronic Graft-Versus-Host Disease (cGVHD) is a condition that can occur after a stem cell or bone marrow transplant, where the donated cells (the graft) attack the recipient's body (the host). This immune response can lead to long-term complications affecting various organs, including the skin, liver, and gastrointestinal tract, and can manifest as rashes, liver dysfunction, and digestive issues.

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High Frequency of Cutaneous Manifestations Including Vitiligo and Alopecia Areata in a Prospective Cohort of Patients with Chronic Graft-Versus-Host Disease

research High Frequency of Cutaneous Manifestations Including Vitiligo and Alopecia Areata in a Prospective Cohort of Patients with Chronic Graft-Versus-Host Disease

17 citations, June 2016 in “Croatian Medical Journal”

Patients with chronic graft-versus-host disease often have skin problems like vitiligo and alopecia areata.

research Human Placental Mesenchymal Stromal Cell-Derived Exosome-Enriched Extracellular Vesicles for Chronic Cutaneous Graft-Versus-Host Disease: A Case Report

13 citations, December 2021 in “Journal of Cellular and Molecular Medicine”

Exosome-enriched vesicles from placental cells improved skin condition in a patient with chronic graft-versus-host disease.

research Non-Malignant Late Cutaneous Changes After Allogeneic Hematopoietic Stem Cell Transplant in Children

7 citations, March 2018 in “Journal of The American Academy of Dermatology”

Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.

research Dermatologic Conditions of the Early Post-Transplant Period in Hematopoietic Stem Cell Transplant Recipients

5 citations, October 2018 in “American Journal of Clinical Dermatology”

Skin problems are common after stem cell transplants, and early treatment by dermatologists can improve patient outcomes.

research Alopecia Universalis and Chronic Graft-Versus-Host Disease Treated With Ruxolitinib

4 citations, October 2018 in “JAMA Dermatology”

Ruxolitinib may help treat hair loss and symptoms in patients with chronic graft-versus-host disease.

Permanent Alopecia as a Manifestation of Chronic Graft-Versus-Host Disease of the Scalp: Clinical, Dermoscopic, and Histopathological Observations

research Permanent Alopecia as a Manifestation of Chronic Graft-Versus-Host Disease of the Scalp: Clinical, Dermoscopic, and Histopathological Observations

2 citations, June 2018 in “Clinical and Experimental Dermatology”

Permanent hair loss after a stem cell transplant can be a sign of chronic immune system attack on the scalp.

research Persistent Facial and Chest Papular and Pustular Eruption in a Stem Cell Transplant Patient

November 2021 in “Transplantation direct”

A 68-year-old man improved after being correctly diagnosed and treated for a skin condition caused by mites, following a stem cell transplant.

research Prevention of Murine Sclerodermatous Chronic Graft-Versus-Host Disease by Rapamycin

January 2013 in “Biology of blood and marrow transplantation”

Rapamycin increased survival in mice with severe chronic graft-versus-host disease by expanding regulatory T cells.

research Combination of Regulatory T Cells and Rapamycin as Treatment for Experimental Chronic Graft-Versus-Host Disease

November 2013 in “Blood”

Using regulatory T cells and Rapamycin together improves chronic graft-versus-host disease treatment outcomes in mice.

research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease

47 citations, June 2013 in “Biology of blood and marrow transplantation”

Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.

research Janus Kinase Inhibitors in Dermatology: A Systematic Review

116 citations, February 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors help with skin conditions but need more research on dosing and safety.

research Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology

63 citations, April 2018 in “Journal of the American Academy of Dermatology”

Topical JAK inhibitors may help treat some skin conditions but need more research.

research Risk Factors and Characterization of Vitiligo and Alopecia Areata in Patients With Chronic Graft-Versus-Host Disease

27 citations, September 2014 in “JAMA dermatology”

Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.

research Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

16 citations, March 2017 in “Bone Marrow Transplantation”

Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

research The Promise and Challenges of Cell Therapy for Psoriasis

15 citations, May 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.

research Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease

2 citations, September 2023 in “Curēus”

Topical spironolactone may help treat ocular graft-versus-host disease with minimal side effects.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations, January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

research Dermatologic Adverse Events from Cancer Treatments

2 citations, October 2018 in “Springer eBooks”

Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.