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This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.

In this study, mice exposed to prolonged space conditions demonstrated skin atrophy, altered hair follicle cycles, and significant changes in the gene expression associated with skin muscle health.

This study observed that using ex vivo gene therapy to modify skin cells in a pre-graft model improved dermal-epidermal junction adhesion strength and maintained collagen production over time, suggesting a potential treatment approach for recessive dystrophic epidermolysis bullosa skin wounds.

Ets2 gene is crucial for placental development in mice.

This commentary argues that adult stem cells are the "gold standard" in regenerative medicine due to their increasing clinical applications and lack of ethical controversy compared to embryonic stem cells.

In this study, prolonged systemic administration of 17β-estradiol in castrated male mice delayed wound healing by inhibiting re-epithelialization and reducing collagen accumulation, with estrogen receptor-α likely mediating this effect.

This review reports that exosome-based therapies, coupled with nanotechnology and AI, show promise in aesthetic medicine, notably in skin rejuvenation and hair restoration, but large-scale trials and clearer regulatory frameworks are needed for effective clinical adoption.

This review found that 5α‐reductase inhibitors were associated with slightly increased rates of decreased libido, erectile and ejaculatory dysfunction, gynecomastia, and mood disorders compared to placebo, though their long-term effects remain unclear.

This review discusses the regenerative properties of exosomes and their potential clinical applications in regenerative medicine, highlighting their role in restoring health and vitality.

This review examines the promising role of nanocarriers, specifically liposomes and ethosomes, in enhancing transdermal drug delivery for skin diseases. Ethosomes, highlighted for their ability to penetrate deeper skin layers, show potential for more effective treatments but require further clinical investigation.

This observational study reviewed thyroid eye disease patients treated with teprotumumab at one center, reporting common side effects like fatigue and dry eye symptoms, with serious adverse events including two cases of blood clots and one pulmonary embolism.

In this study using a mouse model, researchers utilized single-cell RNA sequencing to create a comprehensive cellular atlas of infected versus uninfected wounds, revealing that Enterococcus faecalis infections lead to immunosuppressive changes in skin cells and disrupt normal wound healing processes.

This review discusses the potential benefits and challenges of using extracellular vesicles in aesthetic medicine but reports no new clinical results, highlighting the need for rigorous validation and stronger regulatory oversight.

In a mouse model of infected burns, this study found that treatment with recombinant fusion peptide EK significantly decreased Pseudomonas aeruginosa colony count and improved wound healing rates compared to controls.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

This case study reports successful treatment of partial scalp alopecia secondary to a repaired occipital encephalocele using the tissue expansion technique.

This case study found that isotretinoin treatment achieved complete resolution of erosive pustular dermatosis of the scalp in a patient, suggesting systemic retinoids as a potential treatment option.

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.

This study reported the successful isolation of epithelial stem cells from mouse embryonic skin using a simple culture method, with the cells showing the potential to differentiate into multiple cell types.

This study found that finasteride ethosome formulations with specific ethanol and soya lecithin concentrations significantly enhanced transdermal drug delivery compared to a potential nanogel.

This research observed that 3D electrospun micro/nanofibrous sponges, without using chemical crosslinking agents, supported enhanced cell growth, vascularization, and skin regeneration in diabetic rats compared to 2D fiber membranes, making them promising for 3D tissue regeneration.

KLHL24-mutant stem cells help understand skin and heart disease.

This review discusses current research and interest in extracellular vesicles for applications in plastic surgery and underscores the need for standardized protocols and further evidence to inform clinical use.

This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.

This study explored Black Sea shark liver oil-based emulgels, finding that the addition of borage oil (Gel 2) enhanced the anti-inflammatory and wound healing properties compared to shark liver oil alone (Gel 1) and a reference diclofenac gel, suggesting promising eco-friendly applications in dermatocosmetics.

This systematic review found that estrogen deficiency in postmenopausal women leads to structural and symptomatic changes in genital and cutaneous tissues, with local estrogen therapy providing short-term benefits, while evidence for device-based treatments remains limited and requires larger trials.

This systematic review describes current findings on the use of recombinant epidermal growth factor (rhEGF) for skin aging and wound healing, emphasizing its potential benefits but highlighting the need for more controlled studies to optimize dosing and treatment protocols.