Preparation, Characterization and Evaluation of Finasteride Ethosomes

April 2016 in “ International Journal of Drug Delivery ”

S. Sujatha, G. Sowmya, M. Chaitanya, V S Kumar Reddy, M Monica, K. S. Kumar

finasteride ethosomes transdermal drug delivery ethanol soya lecithin entrapment efficiency Higuchi diffusion mechanism Propecia

TLDR The ethosomal formulation improved finasteride delivery through the skin.

The study focused on developing finasteride ethosomes for transdermal drug delivery, using varying concentrations of ethanol and soya lecithin. The optimal formulation, containing 30% ethanol and 3% soya lecithin, achieved the highest drug release of 82.66% and transdermal flux. The entrapment efficiency was 85.32%, and the drug content was 99.5%. The ethosomes were spherical with uniform size, and ethanol concentration significantly affected entrapment efficiency. The drug release followed first-order kinetics with a Higuchi diffusion mechanism. The ethosomal formulation showed promise for enhancing transdermal delivery of finasteride compared to a nanogel.

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Research cited in this study

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research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations , June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

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community How does low level laser therapy?

in Chat 5 upvotes 7 months ago

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community 5 months fin/min with 3 sessions of laser therapy and Exosomes

in Is this regrowth? 15 upvotes 3 months ago

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in Progress Pictures 10 upvotes 5 months ago

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research Transdermal Drug Delivery of Finasteride Ethosomes and Finasteride Liposomes

1 citations , January 2007 in “Zhōnghuá yàoxué zázhì”

Ethosomes deliver finasteride through the skin more effectively than liposomes.