Transdermal Drug Delivery of Finasteride Ethosomes and Finasteride Liposomes

    January 2007 in “ Zhōnghuá yàoxué zázhì ”
    Wenquan Liang
    TLDR Ethosomes deliver finasteride through the skin more effectively than liposomes.
    The study investigated the permeation characteristics of finasteride encapsulated in ethosomes and liposomes. Ethosomes, prepared by injection, were found to have a more condensed vesicular structure and higher encapsulation ability compared to liposomes, which were prepared by the film dispersing method. The transdermal flux of ethosomes was 1.34±0.11 μg·cm-2·h-1, which was 3.2 times higher than that of liposomes. Ethosomes also significantly increased the skin accumulation of finasteride, particularly in the deeper dermis layers, although the drug distribution ratio between the epidermis and dermis was reversed. The study concluded that the different percutaneous drug delivery characteristics of ethosomes and liposomes were crucial in selecting the appropriate carrier for the desired drug-release profile.
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