Anatomical and Dermatologic Manifestations of Estrogen Deficiency in Postmenopausal Women: A Systematic Review
December 2025
in “
Pakistan Journal of Health Sciences
”
estrogen deficiency postmenopausal women estradiol selective estrogen receptor modulators xerosis pruritus dermatoses nail fragility female-pattern hair loss dermal thickness vaginal wall thickness local estrogen therapy fractional CO₂ laser radiofrequency estrogen SERMs dry skin itching skin disorders brittle nails hair thinning skin thickness vaginal thickness estrogen cream CO2 laser RF treatment
Studysummary This systematic review found that estrogen deficiency in postmenopausal women leads to structural and symptomatic changes in genital and cutaneous tissues, with local estrogen therapy providing short-term benefits, while evidence for device-based treatments remains limited and requires larger trials.
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